E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system

Joana Matos, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, Miguel Campos.


Abstract
Background: Hyperthyroidism is the most frequent endocrinopathy in older cats. To date, there is no consensus on how to best calculate the dose of radioiodine to administer to hyperthyroid cats.
Aim: The goals of this study were to compare thyroid function, renal function and survival time between hyperthyroid cats receiving a fixed dose of radioiodine and those receiving an individualized dose calculated using a clinical scoring system.
Methods: Medical records of 110 cats treated with radioiodine therapy at the University of Bern between 2010 and 2020 were reviewed. Thyroid function, renal function and survival of cats treated with a fixed dose of radioiodine (2010-2015; n= 50) were compared to those of cats treated with an individualized dose (2015-2020; n= 60) at different timepoints after therapy.
Results: Treatment with a fixed dose of radioiodine (mean 168 ± 26 MBq) was associated with 69% of euthyroidism, 19% persistent hyperthyroidism and 12% hypothyroidism, whereas treatment with an individualized dose (mean 120 ± 30 MBq) led to 54% euthyroidism, 23% hyperthyroidism and 23% hypothyroidism (P=0.73).
More than twelve months after treatment, the incidence of azotaemia was comparable between cats treated with a fixed dose (37%) and those treated with an individualized dose (31%) (P= 0.77).
No factors were found to be predictive of treatment failure (hypothyroidism or hyperthyroidism) after therapy.
Median survival time after radioiodine therapy was 44 months. In a multivariate analysis, persistent hyperthyroidism was the only variable independently associated with a shorter survival time (HR= 6.24, P= 0.002).
Conclusion: The method of calculating the dose of radioiodine (fixed vs individualized) to treat feline hyperthyroidism does not appear to be decisive for post-treatment thyroid function, renal function or survival.

Key words: cat; dose; hyperthyroidism; radioiodine.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Joana Matos
Articles by Berenice Lutz
Articles by Lisa-Maria Grandt
Articles by Felix Meneses
Articles by Daniela Schweizer
Articles by Thierry Francey
Articles by Miguel Campos
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J. 2022; 12(2): 231-241. doi:10.5455/OVJ.2022.v12.i2.11


Web Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. https://www.openveterinaryjournal.com/?mno=21277 [Access: March 13, 2024]. doi:10.5455/OVJ.2022.v12.i2.11


AMA (American Medical Association) Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J. 2022; 12(2): 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Vancouver/ICMJE Style

Matos J, BL, Grandt L, Meneses F, Schweizer D, Francey T, Campos M. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J. (2022), [cited March 13, 2024]; 12(2): 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Harvard Style

Matos, J., , . B. L., Grandt, . L., Meneses, . F., Schweizer, . D., Francey, . T. & Campos, . M. (2022) Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Vet J, 12 (2), 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Turabian Style

Matos, Joana, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, and Miguel Campos. 2022. Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Veterinary Journal, 12 (2), 231-241. doi:10.5455/OVJ.2022.v12.i2.11



Chicago Style

Matos, Joana, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, and Miguel Campos. "Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system." Open Veterinary Journal 12 (2022), 231-241. doi:10.5455/OVJ.2022.v12.i2.11



MLA (The Modern Language Association) Style

Matos, Joana, Berenice Lutz, Lisa-Maria Grandt, Felix Meneses, Daniela Schweizer, Thierry Francey, and Miguel Campos. "Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system." Open Veterinary Journal 12.2 (2022), 231-241. Print. doi:10.5455/OVJ.2022.v12.i2.11



APA (American Psychological Association) Style

Matos, J., , . B. L., Grandt, . L., Meneses, . F., Schweizer, . D., Francey, . T. & Campos, . M. (2022) Outcome of radioiodine therapy for feline hyperthyroidism: fixed dose versus individualized dose based on a clinical scoring system. Open Veterinary Journal, 12 (2), 231-241. doi:10.5455/OVJ.2022.v12.i2.11