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Research Article


Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats

Nabil A. Soliman, Amr A. Shalaby, Mayada R. Farag, Shimaa Kamal, Sara M. Abdelkarem Alashqar, Mohamed Ahmed Ammar, Suzan Attia Mawed.


Abstract
Background:
Pain and inflammation are closely associated with rheumatoid arthritis (RA), which affects the bones and joints.

Aim:
While there are a number of therapeutic options for arthritis, their side effects restrict their use and encourage the search for alternative, natural remedies.

Methods:
In male rats, we examined the anti-inflammatory and anti-arthritic properties of Naja haje venom (NHV). Thirty adult albino rats were divided into five equal groups, each consisting of six rats. The1st group kept as control,while the 2nd group (FCA) received an injection of 0.05 mL of Freund's complete adjuvant (FCA) for eight days to induce RA and inflammation. The3rd group (FCA/NHVL) and the4th group (FCA/NHVH) received an injection of FCA followed by an intraperitoneal injection of 0.042 µg/kg (low; L) and 0.085 µg/kg (high; H) of lyophilized NHV, respectively, for 14 days. The5th group (FCA/Indomethacin) received an injection of FCA followed by an intraperitoneal injection of 0.25 mg indomethacin/kg for 14 days.

Results:
This study found that NHVH significantly increased the body's total antioxidant capacity (TAC) after FCA while lowering the levels of interleukinsIL-10 and IL-6, as well as the activity of genes that cause inflammation, like NF-κB and TNF-α. Furthermore, histological findings in NHVH groups showed a partial regeneration of the cartilage, bone, and synovium in the palm and ankle joint compartments.

Conclusion:
All of our findings suggest that NHV has anti-inflammatory and anti-arthritic qualities that may help repair the joint-damaging components caused by FCA and restore cellular equilibrium.

Key words: Rheumatoid Arthritis, Snake venom, Indomethacin, Freund's complete adjuvant, Rats


 
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How to Cite this Article
Pubmed Style

Soliman NA, Shalaby AA, Farag MR, Kamal S, Alashqar SMA, Ammar MA, Mawed SA. Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats. Open Vet J. 2024; 14(11): 2866-2876. doi:10.5455/OVJ.2024.v14.i11.15

Web Style

Soliman NA, Shalaby AA, Farag MR, Kamal S, Alashqar SMA, Ammar MA, Mawed SA. Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats. https://www.openveterinaryjournal.com/?mno=214271 [Access: December 07, 2024]. doi:10.5455/OVJ.2024.v14.i11.15

AMA (American Medical Association) Style

Soliman NA, Shalaby AA, Farag MR, Kamal S, Alashqar SMA, Ammar MA, Mawed SA. Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats. Open Vet J. 2024; 14(11): 2866-2876. doi:10.5455/OVJ.2024.v14.i11.15


Vancouver/ICMJE Style

Soliman NA, Shalaby AA, Farag MR, Kamal S, Alashqar SMA, Ammar MA, Mawed SA. Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats. Open Vet J. (2024), [cited December 07, 2024]; 14(11): 2866-2876. doi:10.5455/OVJ.2024.v14.i11.15


Harvard Style

Soliman, N. A., Shalaby, . A. A., Farag, . M. R., Kamal, . S., Alashqar, . S. M. A., Ammar, . M. A. & Mawed, . S. A. (2024) Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats. Open Vet J, 14 (11), 2866-2876. doi:10.5455/OVJ.2024.v14.i11.15


Turabian Style

Soliman, Nabil A., Amr A. Shalaby, Mayada R. Farag, Shimaa Kamal, Sara M. Abdelkarem Alashqar, Mohamed Ahmed Ammar, and Suzan Attia Mawed. 2024. Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats. Open Veterinary Journal, 14 (11), 2866-2876. doi:10.5455/OVJ.2024.v14.i11.15


Chicago Style

Soliman, Nabil A., Amr A. Shalaby, Mayada R. Farag, Shimaa Kamal, Sara M. Abdelkarem Alashqar, Mohamed Ahmed Ammar, and Suzan Attia Mawed. "Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats." Open Veterinary Journal 14 (2024), 2866-2876. doi:10.5455/OVJ.2024.v14.i11.15


MLA (The Modern Language Association) Style

Soliman, Nabil A., Amr A. Shalaby, Mayada R. Farag, Shimaa Kamal, Sara M. Abdelkarem Alashqar, Mohamed Ahmed Ammar, and Suzan Attia Mawed. "Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats." Open Veterinary Journal 14.11 (2024), 2866-2876. Print. doi:10.5455/OVJ.2024.v14.i11.15


APA (American Psychological Association) Style

Soliman, N. A., Shalaby, . A. A., Farag, . M. R., Kamal, . S., Alashqar, . S. M. A., Ammar, . M. A. & Mawed, . S. A. (2024) Ameliorative effect of Naja haje venom against arthritic influence of Freund’s complete adjuvant FCA in paw and ankle of male rats. Open Veterinary Journal, 14 (11), 2866-2876. doi:10.5455/OVJ.2024.v14.i11.15


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