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Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats

Putri Reno Intan, Sukmayati Alegantina, Ani Isnawati, Nanang Yunarto, Fitrine Ekawasti, Ratih Rinendyaputri, Sunarno Sunarno, Yulvian Sani, Sela Septima Mariya, Ekowati Handharyani.


Abstract
Background:
Breastfeeding is vital for infant health, providing essential nutrients and protection against infections. Despite the benefits, many postpartum women face challenges in breastfeeding due to hypogalactia caused by stress, anxiety, or maternal illness. While medications like metoclopramide and domperidone are sometimes prescribed to increase milk supply, they are limited due to safety concerns. As a result, there is a growing interest in alternative nonpharmacological interventions, including herbal galactagogues. Plants such as Sauropus androgynus, Moringa oleifera, and Coleus amboinicus have shown potential in enhancing milk production due to their unique lactogenic properties.

Aim:
This study aimed to investigate the influence of a combination of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus extracts on milk production while assessing whether these extracts possess galactagogue properties.

Methods:
Twenty-four Sprague-Dawley rats were randomly divided into four groups at parturition. Each group, comprising six dams, was assigned a specific dose of 37.5, 75, and 150 mg/kg of the blended extract orally for 20 days postpartum, with one group serving as the control. Mammary glands were harvested and assayed for prolactin expression by immunohistochemistry.

Results:
The results showed that, while the rate of milk production did not increase linearly with the duration of lactation, rats treated with the blended extract at a dose of 75 mg/kg exhibited higher milk production than the control group. Immunohistochemical analysis revealed increased prolactin expression in the mammary glands of rats treated with blend extract at 37.5 mg/kg (p<0.05), suggesting its potential as a galactagogue.

Conclusion:
The blended extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus may stimulate milk production by modulating prolactin expression and mammary gland morphology.

Key words: Coleus amboinicus, Immunohistochemistry, Mammary glands, Moringa oleifera, Sauropus androgynus


 
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How to Cite this Article
Pubmed Style

Intan PR, Alegantina S, Isnawati A, Yunarto N, Ekawasti F, Rinendyaputri R, Sunarno S, Sani Y, Mariya SS, Handharyani E. Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats. Open Vet J. 2024; 14(12): 3630-3639. doi:10.5455/OVJ.2024.v14.i12.44

Web Style

Intan PR, Alegantina S, Isnawati A, Yunarto N, Ekawasti F, Rinendyaputri R, Sunarno S, Sani Y, Mariya SS, Handharyani E. Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats. https://www.openveterinaryjournal.com/?mno=218447 [Access: January 22, 2025]. doi:10.5455/OVJ.2024.v14.i12.44

AMA (American Medical Association) Style

Intan PR, Alegantina S, Isnawati A, Yunarto N, Ekawasti F, Rinendyaputri R, Sunarno S, Sani Y, Mariya SS, Handharyani E. Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats. Open Vet J. 2024; 14(12): 3630-3639. doi:10.5455/OVJ.2024.v14.i12.44


Vancouver/ICMJE Style

Intan PR, Alegantina S, Isnawati A, Yunarto N, Ekawasti F, Rinendyaputri R, Sunarno S, Sani Y, Mariya SS, Handharyani E. Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats. Open Vet J. (2024), [cited January 22, 2025]; 14(12): 3630-3639. doi:10.5455/OVJ.2024.v14.i12.44


Harvard Style

Intan, P. R., Alegantina, . S., Isnawati, . A., Yunarto, . N., Ekawasti, . F., Rinendyaputri, . R., Sunarno, . S., Sani, . Y., Mariya, . S. S. & Handharyani, . E. (2024) Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats. Open Vet J, 14 (12), 3630-3639. doi:10.5455/OVJ.2024.v14.i12.44


Turabian Style

Intan, Putri Reno, Sukmayati Alegantina, Ani Isnawati, Nanang Yunarto, Fitrine Ekawasti, Ratih Rinendyaputri, Sunarno Sunarno, Yulvian Sani, Sela Septima Mariya, and Ekowati Handharyani. 2024. Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats. Open Veterinary Journal, 14 (12), 3630-3639. doi:10.5455/OVJ.2024.v14.i12.44


Chicago Style

Intan, Putri Reno, Sukmayati Alegantina, Ani Isnawati, Nanang Yunarto, Fitrine Ekawasti, Ratih Rinendyaputri, Sunarno Sunarno, Yulvian Sani, Sela Septima Mariya, and Ekowati Handharyani. "Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats." Open Veterinary Journal 14 (2024), 3630-3639. doi:10.5455/OVJ.2024.v14.i12.44


MLA (The Modern Language Association) Style

Intan, Putri Reno, Sukmayati Alegantina, Ani Isnawati, Nanang Yunarto, Fitrine Ekawasti, Ratih Rinendyaputri, Sunarno Sunarno, Yulvian Sani, Sela Septima Mariya, and Ekowati Handharyani. "Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats." Open Veterinary Journal 14.12 (2024), 3630-3639. Print. doi:10.5455/OVJ.2024.v14.i12.44


APA (American Psychological Association) Style

Intan, P. R., Alegantina, . S., Isnawati, . A., Yunarto, . N., Ekawasti, . F., Rinendyaputri, . R., Sunarno, . S., Sani, . Y., Mariya, . S. S. & Handharyani, . E. (2024) Effects of a blend extract of Sauropus androgynus, Moringa oleifera, and Coleus amboinicus on milk production in lactating rats. Open Veterinary Journal, 14 (12), 3630-3639. doi:10.5455/OVJ.2024.v14.i12.44


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