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Research Article


Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares

Amal M. Aboelmaaty, Abdalla E. A. Elgharieb, Hazem A. El-Debaky, Jamal M. H. Alkhadrawy, Mostafa M. Abou-Ahmed, Abdelraouf M. Ghallab.


Abstract
Background:
Senility influences fertility in women and companion animals specially horses.

Aim:
This study aimed to investigate the effect of aging in horses on the daily changes in the dominant follicle dynamics and hemodynamics, antimüllerian hormone, enzymes, antioxidants, and ovarian hormones during the estrous cycle.

Methods:
Ovaries of old mares (n=5, age >20 years) and young native mares (n=6, age <10 years). were scanned during 6 different estrous cycles from March 2022 to August 2023 with Doppler ultrasound. The dominant follicle (DF) diameter and color area, the corpus luteum (CL) diameter and the uterine horn area and color area were determined. In collected blood samples with each ultrasound and Doppler scanning, antimüllerian hormone (AMH), estradiol (E2), progesterone (P4), cholesterol, myeloperoxidase (MPO), catalase (CAT), glutathione peroxidase (GPx), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and nitric oxide (NO) concentrations were determined.

Results:
Age significantly affected the dominant follicle area (P<0.0001), color area (P<0.0001), color area % (P=0.020), CL area (P=0.033), uterine horn area (P<0.0001), ovarian artery pulsatility index (PI, P<0.05), E2 (P<0.001), Cholesterol (P<0.0001), LDH (P<0.0001), and NO (P<0.0001). Aging tended (P>0.05) to decrease the dominant follicle antrum diameter but significantly decreased (P<0.05) its area, antrum area, and color area % in addition to the decrease (P<0.01) in the uterine horn diameter and area, estradiol, total cholesterol, LDH, NO, Aging increased (P<0.05) CL area and the ovarian artery pulsatility index (PI) and tended (P>0.05) to increase the ovarian artery resistance index(RI).

Conclusion:
Aging in mares did not disturb AMH, the ovarian macro-environmental dynamics, follicle growth, and recruiting but the disrupted blood flow mediators, enzymes, antioxidant status may affect the intrafollicular mediators influence the oocyte quality.

Key words: Keywords: Mares, Aging, Antimüllerian hormone, Ovarian hormones, Luteal dynamics


 
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How to Cite this Article
Pubmed Style

Aboelmaaty AM, Elgharieb AEA, El-Debaky HA, Alkhadrawy JMH, Abou-Ahmed MM, Ghallab AM. Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares. Open Vet J. 2024; 14(11): 3132-3143. doi:10.5455/OVJ.2024.v14.i11.44

Web Style

Aboelmaaty AM, Elgharieb AEA, El-Debaky HA, Alkhadrawy JMH, Abou-Ahmed MM, Ghallab AM. Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares. https://www.openveterinaryjournal.com/?mno=222067 [Access: December 06, 2024]. doi:10.5455/OVJ.2024.v14.i11.44

AMA (American Medical Association) Style

Aboelmaaty AM, Elgharieb AEA, El-Debaky HA, Alkhadrawy JMH, Abou-Ahmed MM, Ghallab AM. Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares. Open Vet J. 2024; 14(11): 3132-3143. doi:10.5455/OVJ.2024.v14.i11.44


Vancouver/ICMJE Style

Aboelmaaty AM, Elgharieb AEA, El-Debaky HA, Alkhadrawy JMH, Abou-Ahmed MM, Ghallab AM. Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares. Open Vet J. (2024), [cited December 06, 2024]; 14(11): 3132-3143. doi:10.5455/OVJ.2024.v14.i11.44


Harvard Style

Aboelmaaty, A. M., Elgharieb, . A. E. A., El-Debaky, . H. A., Alkhadrawy, . J. M. H., Abou-Ahmed, . M. M. & Ghallab, . A. M. (2024) Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares. Open Vet J, 14 (11), 3132-3143. doi:10.5455/OVJ.2024.v14.i11.44


Turabian Style

Aboelmaaty, Amal M., Abdalla E. A. Elgharieb, Hazem A. El-Debaky, Jamal M. H. Alkhadrawy, Mostafa M. Abou-Ahmed, and Abdelraouf M. Ghallab. 2024. Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares. Open Veterinary Journal, 14 (11), 3132-3143. doi:10.5455/OVJ.2024.v14.i11.44


Chicago Style

Aboelmaaty, Amal M., Abdalla E. A. Elgharieb, Hazem A. El-Debaky, Jamal M. H. Alkhadrawy, Mostafa M. Abou-Ahmed, and Abdelraouf M. Ghallab. "Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares." Open Veterinary Journal 14 (2024), 3132-3143. doi:10.5455/OVJ.2024.v14.i11.44


MLA (The Modern Language Association) Style

Aboelmaaty, Amal M., Abdalla E. A. Elgharieb, Hazem A. El-Debaky, Jamal M. H. Alkhadrawy, Mostafa M. Abou-Ahmed, and Abdelraouf M. Ghallab. "Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares." Open Veterinary Journal 14.11 (2024), 3132-3143. Print. doi:10.5455/OVJ.2024.v14.i11.44


APA (American Psychological Association) Style

Aboelmaaty, A. M., Elgharieb, . A. E. A., El-Debaky, . H. A., Alkhadrawy, . J. M. H., Abou-Ahmed, . M. M. & Ghallab, . A. M. (2024) Fluctuations of antimüllerian hormone, ovarian follicular reserve, and antioxidant status throughout the estrous cycle in aged mares. Open Veterinary Journal, 14 (11), 3132-3143. doi:10.5455/OVJ.2024.v14.i11.44


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