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Research Article


Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats

Mio Ishizaka, Huai-hsun Hsu, Yuichi Miyagawa, Naoyuki Takemura.


Abstract
Background:
Omecamtiv mecarbil (OM), a selective cardiac myosin activator, is gaining attention as a potential heart failure treatment because it can enhance cardiac contractility without adverse effects. Concerns were raised about arrhythmias with conventional heart failure treatments in cats. Despite OM’s promise in veterinary medicine, no studies have confirmed its efficacy in cats.

Aim:
This study aimed to investigate the pharmacodynamics of OM in cats.

Methods:
Five clinically healthy cats were used. OM’s efficacy was examined in three doses: 0.1, 0.25, and 1.0 mg/kg. To minimize the effect on heart rates, the cats were under general anesthesia, and baseline measurements were taken after the heart rate and blood pressure had stabilized. OM was administered as a single intravenous injection. Echocardiography was performed 15, 30, 60, 90, and 120 min after administration. Heart rate and blood pressure were measured before each echocardiographic examination.

Results:
The heart rates decreased at all doses; significant reductions were seen at 0.25 and 1.0 mg/kg. All doses enhanced cardiac contractility, showing a dose-dependent effect. Blood pressure remained unchanged.

Conclusion:
OM enhances cardiac contractility in cats, with 0.25 mg/kg being the optimal dose.

Key words: Omecamtiv mecarbil, Feline, Heart failure, Cardiomyopathy


 
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How to Cite this Article
Pubmed Style

Ishizaka M, Hsu H, Miyagawa Y, Takemura N. Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats. Open Vet J. 2024; 14(12): 3614-3624. doi:10.5455/OVJ.2024.v14.i12.42

Web Style

Ishizaka M, Hsu H, Miyagawa Y, Takemura N. Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats. https://www.openveterinaryjournal.com/?mno=223493 [Access: January 22, 2025]. doi:10.5455/OVJ.2024.v14.i12.42

AMA (American Medical Association) Style

Ishizaka M, Hsu H, Miyagawa Y, Takemura N. Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats. Open Vet J. 2024; 14(12): 3614-3624. doi:10.5455/OVJ.2024.v14.i12.42


Vancouver/ICMJE Style

Ishizaka M, Hsu H, Miyagawa Y, Takemura N. Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats. Open Vet J. (2024), [cited January 22, 2025]; 14(12): 3614-3624. doi:10.5455/OVJ.2024.v14.i12.42


Harvard Style

Ishizaka, M., Hsu, . H., Miyagawa, . Y. & Takemura, . N. (2024) Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats. Open Vet J, 14 (12), 3614-3624. doi:10.5455/OVJ.2024.v14.i12.42


Turabian Style

Ishizaka, Mio, Huai-hsun Hsu, Yuichi Miyagawa, and Naoyuki Takemura. 2024. Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats. Open Veterinary Journal, 14 (12), 3614-3624. doi:10.5455/OVJ.2024.v14.i12.42


Chicago Style

Ishizaka, Mio, Huai-hsun Hsu, Yuichi Miyagawa, and Naoyuki Takemura. "Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats." Open Veterinary Journal 14 (2024), 3614-3624. doi:10.5455/OVJ.2024.v14.i12.42


MLA (The Modern Language Association) Style

Ishizaka, Mio, Huai-hsun Hsu, Yuichi Miyagawa, and Naoyuki Takemura. "Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats." Open Veterinary Journal 14.12 (2024), 3614-3624. Print. doi:10.5455/OVJ.2024.v14.i12.42


APA (American Psychological Association) Style

Ishizaka, M., Hsu, . H., Miyagawa, . Y. & Takemura, . N. (2024) Pharmacodynamics of single-dose omecamtiv mecarbil administered intravenously in clinically healthy cats. Open Veterinary Journal, 14 (12), 3614-3624. doi:10.5455/OVJ.2024.v14.i12.42


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