Abstract
Background:
Cadmium is a common environmental pollutant that causes severe health issues. Many studies have proposed antioxidant foods to combat cadmium toxicity. One such antioxidant agent is caffeine, and hence, this study investigated its effects.

Aim:
To investigate the effect of caffeine as an antioxidant agent against cadmium toxicity

Methods:
Twelve male albino mice were divided into three groups of four: Group 1: Administered 1 ml of saline orally for 7 days and injected with 1 ml of saline subcutaneously (S/C) on the eighth day. Group 2: Patients orally administered 1 ml of saline for 7 days and injected with 1-ml of CdCl2 S/C on the eighth day. Group 3: Administered 1 ml of caffeine orally for seven days and injected with CdCl2 S/C on the eighth day.

Results:
Results showed that caffeine can reduce cadmium-induced testicular hemorrhage, lung injury, and kidney injury. Additionally, caffeine was found to significantly reduce the cadmium-induced inflammatory response in lung-associated lymphoid tissue.

Conclusion:
These findings suggest that the daily intake of caffeine could protect against cadmium toxicity.

Key words: Antioxidant, Cadmium, Caffeine, Heavy metal