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Case Report


Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report

Alan Maksimović, Bianca Pehar, Nermina Spahija, Selma Filipović, Muamer Obhodas, Kenan Tabaković, Alma Seho-alić, Jovana Dervović, Amer Alić.


Abstract
Background:
Hepatobiliary tumors are uncommon in dogs, and metastatic liver tumors are diagnosed more frequently than primary liver tumors. Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignant tumor.

Case Description:
An 11-year-old spayed female Tibetan Terrier was referred to the University of Sarajevo Veterinary Teaching Hospital due to recurrent painful urination attempts, straining urination, hematuria, and decreased appetite. Abdominal ultrasonography revealed a moderately distended bladder containing urolith, bladder wall thickening, and sediment. Incidentally, a hyperechoic hepatic mass on the left medial liver lobe and hepatomegaly were detected along with gallbladder sludge. Surgical cystolithotomy and partial liver lobectomy were performed. Histopathological examination confirmed the hepatic mass as clear cell hepatocellular carcinoma (CCHCC).

Conclusion:
Although this rare histological subtype has been documented, its biological behavior and clinical features remain poorly understood due to the scarcity of cases. A recent publication by Jung et al. (2021) described the first cytological, histological, and clinical case presentation of CCHCC in dogs, suggesting that obesity and hyperlipidemia may be potential risk factors. However, these proposed risk factors were not detected in the present case, implying that CCHCC in dogs is a rare and poorly understood condition that warrants further attention in veterinary research.

Key words: Clear cell hepatocellular carcinoma, Dog, Case report


 
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How to Cite this Article
Pubmed Style

Maksimović A, Pehar B, Spahija N, Filipović S, Obhodas M, Tabaković K, Seho-alić A, Dervović J, Alić A. Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report. Open Vet J. 2025; 15(5): 2265-2269. doi:10.5455/OVJ.2025.v15.i5.44

Web Style

Maksimović A, Pehar B, Spahija N, Filipović S, Obhodas M, Tabaković K, Seho-alić A, Dervović J, Alić A. Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report. https://www.openveterinaryjournal.com/?mno=241411 [Access: June 06, 2025]. doi:10.5455/OVJ.2025.v15.i5.44

AMA (American Medical Association) Style

Maksimović A, Pehar B, Spahija N, Filipović S, Obhodas M, Tabaković K, Seho-alić A, Dervović J, Alić A. Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report. Open Vet J. 2025; 15(5): 2265-2269. doi:10.5455/OVJ.2025.v15.i5.44


Vancouver/ICMJE Style

Maksimović A, Pehar B, Spahija N, Filipović S, Obhodas M, Tabaković K, Seho-alić A, Dervović J, Alić A. Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report. Open Vet J. (2025), [cited June 06, 2025]; 15(5): 2265-2269. doi:10.5455/OVJ.2025.v15.i5.44


Harvard Style

Maksimović, A., Pehar, . B., Spahija, . N., Filipović, . S., Obhodas, . M., Tabaković, . K., Seho-alić, . A., Dervović, . J. & Alić, . A. (2025) Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report. Open Vet J, 15 (5), 2265-2269. doi:10.5455/OVJ.2025.v15.i5.44


Turabian Style

Maksimović, Alan, Bianca Pehar, Nermina Spahija, Selma Filipović, Muamer Obhodas, Kenan Tabaković, Alma Seho-alić, Jovana Dervović, and Amer Alić. 2025. Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report. Open Veterinary Journal, 15 (5), 2265-2269. doi:10.5455/OVJ.2025.v15.i5.44


Chicago Style

Maksimović, Alan, Bianca Pehar, Nermina Spahija, Selma Filipović, Muamer Obhodas, Kenan Tabaković, Alma Seho-alić, Jovana Dervović, and Amer Alić. "Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report." Open Veterinary Journal 15 (2025), 2265-2269. doi:10.5455/OVJ.2025.v15.i5.44


MLA (The Modern Language Association) Style

Maksimović, Alan, Bianca Pehar, Nermina Spahija, Selma Filipović, Muamer Obhodas, Kenan Tabaković, Alma Seho-alić, Jovana Dervović, and Amer Alić. "Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report." Open Veterinary Journal 15.5 (2025), 2265-2269. Print. doi:10.5455/OVJ.2025.v15.i5.44


APA (American Psychological Association) Style

Maksimović, A., Pehar, . B., Spahija, . N., Filipović, . S., Obhodas, . M., Tabaković, . K., Seho-alić, . A., Dervović, . J. & Alić, . A. (2025) Clear cell hepatocellular carcinoma incidentally detected in an 11-year-old female Tibetan Terrier dog: A case report. Open Veterinary Journal, 15 (5), 2265-2269. doi:10.5455/OVJ.2025.v15.i5.44


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