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Research Article


Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats

Iman Hussein Naser, Zahraa Abed Al-kareem, Moayad Mijbil Ubaid, Shatha Hussein Kadhim.


Abstract
Background:
Acetaminophen has an antipyretic activity by inhibiting prostaglandin synthesis found in the brain, and this action is responsible for its analgesic effect, but overdose can cause hepatic and renal toxicity. Coenzyme Q10 has cytoprotective properties through antioxidant and anti-inflammatory effects. In addition, it plays a role in energy production in the mitochondria, making it important in improving cellular damage by toxic agents.

Aim:
This study aimed to evaluate the potential protective effect of CoQ10 against acetaminophen toxicity on liver and kidney functions.

Methods:
Thirty adult male albino rats were randomly subdivided into three groups: control group, acetaminophen group, acetaminophen + CoQ10 group, acetaminophen in toxic dose (500mg/kg) orally, and acetaminophen + CoQ10 group, drenched with coenzymeQ10 (10 mg/kg) orally, then acetaminophen in toxic dose (500 mg/kg). Dosing continued for 30 days. Blood was collected for biochemical analysis of hepatic and renal biochemical parameters.

Results:
Acetaminophen induced hepatic injury as measured by increased hepatic biochemical parameters “Total serum bilirubin (TSB), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)” (P≤0.05). The third group, which received acetaminophen plus CoQ10, had a significant decrease in hepatic biochemical markers(P≤0.05). The drenched of acetaminophen increased (creatinine and albumin), whereas the treatment with CoQ10 reduced their levels.

Conclusion:
Coenzyme Q10 can reduce the toxicity of acetaminophen overdose by acting as an antioxidant agent that reduces tissue and organ damage.

Key words: Acetaminophen toxicity; Antioxidant; Hepatic enzymes; Nephrotoxicity; Oxidative stress.


 
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How to Cite this Article
Pubmed Style

Naser IH, Al-kareem ZA, Ubaid MM, Kadhim SH. Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats. Open Vet. J.. 2025; 15(9): 4235-4241. doi:10.5455/OVJ.2025.v15.i9.29

Web Style

Naser IH, Al-kareem ZA, Ubaid MM, Kadhim SH. Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats. https://www.openveterinaryjournal.com/?mno=266904 [Access: October 07, 2025]. doi:10.5455/OVJ.2025.v15.i9.29

AMA (American Medical Association) Style

Naser IH, Al-kareem ZA, Ubaid MM, Kadhim SH. Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats. Open Vet. J.. 2025; 15(9): 4235-4241. doi:10.5455/OVJ.2025.v15.i9.29


Vancouver/ICMJE Style

Naser IH, Al-kareem ZA, Ubaid MM, Kadhim SH. Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats. Open Vet. J.. (2025), [cited October 07, 2025]; 15(9): 4235-4241. doi:10.5455/OVJ.2025.v15.i9.29


Harvard Style

Naser, I. H., Al-kareem, . Z. A., Ubaid, . M. M. & Kadhim, . S. H. (2025) Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats. Open Vet. J., 15 (9), 4235-4241. doi:10.5455/OVJ.2025.v15.i9.29


Turabian Style

Naser, Iman Hussein, Zahraa Abed Al-kareem, Moayad Mijbil Ubaid, and Shatha Hussein Kadhim. 2025. Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats. Open Veterinary Journal, 15 (9), 4235-4241. doi:10.5455/OVJ.2025.v15.i9.29


Chicago Style

Naser, Iman Hussein, Zahraa Abed Al-kareem, Moayad Mijbil Ubaid, and Shatha Hussein Kadhim. "Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats." Open Veterinary Journal 15 (2025), 4235-4241. doi:10.5455/OVJ.2025.v15.i9.29


MLA (The Modern Language Association) Style

Naser, Iman Hussein, Zahraa Abed Al-kareem, Moayad Mijbil Ubaid, and Shatha Hussein Kadhim. "Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats." Open Veterinary Journal 15.9 (2025), 4235-4241. Print. doi:10.5455/OVJ.2025.v15.i9.29


APA (American Psychological Association) Style

Naser, I. H., Al-kareem, . Z. A., Ubaid, . M. M. & Kadhim, . S. H. (2025) Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats. Open Veterinary Journal, 15 (9), 4235-4241. doi:10.5455/OVJ.2025.v15.i9.29


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