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Research Article


Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats

Amal Umran Mosa, Moayed Mijbil Ubaid, Sarah Najm Abed, Shatha Hussein Kadhim.


Abstract
Background:
Gentamicin is widespread aminoglycoside antibiotic related to liver and renal toxicity, to evaluate the protective role of the bioactive constituents of Malva parviflora through their antioxidant and anti-inflammatory actions.

Aim:
The aim of the study is to assess the Malva parviflora extract influence on liver and renal toxicity in albino rats’ male result from gentamicin intramuscular injection.

Methods:
Twenty - four albino rats were partitioned arbitrarily into four groups; control group, gentamicin treated group for thirty days, Malva parviflora extract treated group for thirty days and gentamicin and Malva combined treated group. Blood biomarkers were analyzed including ALT, AST, creatinine and oxidative stress biomarker; MDA, GSH and GST as well as evaluation the histopathological alteration in liver and kidney were performed. with p-value ≤ 0.05 is rated as significant statistically.

Results:
Significant increase in ALT, AST and creatinine levels and liver and renal histology exams reveal marked alterations in gentamicin use. These alterations were attenuated by combining Malva parviflora extract and preserving tissue structures and organ’s functions near normal. Malva parviflora reverses the oxidative stress of gentamicin by lowering the concentration of MDA and recovers the levels of GSH and GST that are seen in group treated with gentamicin plus Malva parviflora

Conclusion:
Gentamicin-induced renal and hepatic toxicities can be reduced significantly by Malva parviflora extract and protect organs.

Key words: Malva parviflora; Gentamicin; Hepatotoxicity; Nephrotoxicity; Oxidative stress.


 
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How to Cite this Article
Pubmed Style

Mosa AU, Ubaid MM, Abed SN, Kadhim SH. Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats. Open Vet. J.. 2025; 15(12): 6434-6441. doi:10.5455/OVJ.2025.v15.i12.28

Web Style

Mosa AU, Ubaid MM, Abed SN, Kadhim SH. Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats. https://www.openveterinaryjournal.com/?mno=273597 [Access: December 31, 2025]. doi:10.5455/OVJ.2025.v15.i12.28

AMA (American Medical Association) Style

Mosa AU, Ubaid MM, Abed SN, Kadhim SH. Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats. Open Vet. J.. 2025; 15(12): 6434-6441. doi:10.5455/OVJ.2025.v15.i12.28


Vancouver/ICMJE Style

Mosa AU, Ubaid MM, Abed SN, Kadhim SH. Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats. Open Vet. J.. (2025), [cited December 31, 2025]; 15(12): 6434-6441. doi:10.5455/OVJ.2025.v15.i12.28


Harvard Style

Mosa, A. U., Ubaid, . M. M., Abed, . S. N. & Kadhim, . S. H. (2025) Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats. Open Vet. J., 15 (12), 6434-6441. doi:10.5455/OVJ.2025.v15.i12.28


Turabian Style

Mosa, Amal Umran, Moayed Mijbil Ubaid, Sarah Najm Abed, and Shatha Hussein Kadhim. 2025. Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats. Open Veterinary Journal, 15 (12), 6434-6441. doi:10.5455/OVJ.2025.v15.i12.28


Chicago Style

Mosa, Amal Umran, Moayed Mijbil Ubaid, Sarah Najm Abed, and Shatha Hussein Kadhim. "Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats." Open Veterinary Journal 15 (2025), 6434-6441. doi:10.5455/OVJ.2025.v15.i12.28


MLA (The Modern Language Association) Style

Mosa, Amal Umran, Moayed Mijbil Ubaid, Sarah Najm Abed, and Shatha Hussein Kadhim. "Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats." Open Veterinary Journal 15.12 (2025), 6434-6441. Print. doi:10.5455/OVJ.2025.v15.i12.28


APA (American Psychological Association) Style

Mosa, A. U., Ubaid, . M. M., Abed, . S. N. & Kadhim, . S. H. (2025) Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats. Open Veterinary Journal, 15 (12), 6434-6441. doi:10.5455/OVJ.2025.v15.i12.28


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