E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 2
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Original Article


Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism

Diego D Miceli, Patricia Noemi Vidal, María Fernanda Cabrera Batter, Omar Pignataro, Victor Alejandro Castillo.

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Abstract
Hypercortisolism induces a state of insulin resistance that can occur concurrently with fasting hyperglycaemia, dyslipidaemia and diabetes mellitus. Metformin reduces hepatic glucose production and insulin resistance of the skeletal muscle and adipose tissue. The aim of this study was to evaluate the effects of metformin on the control of metabolic disorders of dogs with hyperadrenocorticism (HAC). Twenty-three dogs with HAC were randomly divided into two groups, consisting of a control group and a metformin group (10 mg metformin/kg/12 h). Both groups received the same treatment for HAC. At baseline and 3 months, blood glucose, total cholesterol, triglyceride and insulin concentrations, in addition to urinary cortisol:creatinine ratio, Homeostatic Model Assessment (HOMA) for insulin sensitivity and β-cell function were measured. Dogs treated with metformin showed significantly reduced glycaemia, cholesterolaemia and triglyceridaemia. They also presented reduced hyperinsulinism and insulin resistance, as well as improved pancreatic β-cell function. The implementation of metformin as an adjuvant therapy is effective for the normalisation of metabolic disorders of dogs with HAC.

Key words: metfomin, hyperadrenocorticism, insulin resistance, dyslipidaemia


 
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How to Cite this Article
Pubmed Style

Miceli DD, Vidal PN, Batter MFC, Pignataro O, Castillo VA. Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. Open Vet J. 2018; 8(2): 193-199. doi:10.4314/ovj.v8i2.13

Web Style

Miceli DD, Vidal PN, Batter MFC, Pignataro O, Castillo VA. Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. https://www.openveterinaryjournal.com/?mno=282461 [Access: March 18, 2025]. doi:10.4314/ovj.v8i2.13

AMA (American Medical Association) Style

Miceli DD, Vidal PN, Batter MFC, Pignataro O, Castillo VA. Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. Open Vet J. 2018; 8(2): 193-199. doi:10.4314/ovj.v8i2.13


Vancouver/ICMJE Style

Miceli DD, Vidal PN, Batter MFC, Pignataro O, Castillo VA. Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. Open Vet J. (2018), [cited March 18, 2025]; 8(2): 193-199. doi:10.4314/ovj.v8i2.13


Harvard Style

Miceli, D. D., Vidal, . P. N., Batter, . M. F. C., Pignataro, . O. & Castillo, . V. A. (2018) Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. Open Vet J, 8 (2), 193-199. doi:10.4314/ovj.v8i2.13


Turabian Style

Miceli, Diego D, Patricia Noemi Vidal, María Fernanda Cabrera Batter, Omar Pignataro, and Victor Alejandro Castillo. 2018. Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. Open Veterinary Journal, 8 (2), 193-199. doi:10.4314/ovj.v8i2.13


Chicago Style

Miceli, Diego D, Patricia Noemi Vidal, María Fernanda Cabrera Batter, Omar Pignataro, and Victor Alejandro Castillo. "Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism." Open Veterinary Journal 8 (2018), 193-199. doi:10.4314/ovj.v8i2.13


MLA (The Modern Language Association) Style

Miceli, Diego D, Patricia Noemi Vidal, María Fernanda Cabrera Batter, Omar Pignataro, and Victor Alejandro Castillo. "Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism." Open Veterinary Journal 8.2 (2018), 193-199. Print. doi:10.4314/ovj.v8i2.13


APA (American Psychological Association) Style

Miceli, D. D., Vidal, . P. N., Batter, . M. F. C., Pignataro, . O. & Castillo, . V. A. (2018) Metformin reduces insulin resistance and the tendency toward hyperglycaemia and dyslipidaemia in dogs with hyperadrenocorticism. Open Veterinary Journal, 8 (2), 193-199. doi:10.4314/ovj.v8i2.13


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