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Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats

L.A. Denzoin Vulcano1,*, O. Confalonieri2, R. Franci2, M.O. Tapia1 and A.L. Soraci1.


Abstract
Acetaminophen (APAP) administration results in hepatotoxicity and hematotoxicity in cats. The response to three different treatments against APAP poisoning was evaluated. Free glutathione (GSH) (200mg/kg), niosomal GSH (14 mg/kg) and free amino acids (180 mg/kg of N-acetylcysteine and 280 mg/kg of methionine) were administered to cats that were intoxicated with APAP (a single dose of 150 mg/kg, p.o.). Serum concentration of alanine aminotransferase (ALT) along with serum, liver and erythrocyte concentration of GSH and methemoglobin percentage were measured before and 4, 24 and 72 hours after APAP administration. Free GSH (200 mg/kg) and niosomal GSH (14 mg/kg) were effective in reducing hepatotoxicity and hematotoxicity in cats intoxicated with a dose of 150 mg/kg APAP. We conclude that both types of treatments can protect the liver and haemoglobin against oxidative stress in APAP intoxicated cats. Furthermore, our results showed that treatment with niosomal GSH represents an effective therapeutic approach for APAP poisoning.

Key words: Acetaminophen toxicity, Cats, Glutathione, Niosomes.


 
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How to Cite this Article
Pubmed Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J. 2013; 3(1): 56-63. doi:10.5455/OVJ.2013.v3.i1.p56

Web Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. https://www.openveterinaryjournal.com/?mno=302656876 [Access: April 10, 2024]. doi:10.5455/OVJ.2013.v3.i1.p56

AMA (American Medical Association) Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J. 2013; 3(1): 56-63. doi:10.5455/OVJ.2013.v3.i1.p56


Vancouver/ICMJE Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J. (2013), [cited April 10, 2024]; 3(1): 56-63. doi:10.5455/OVJ.2013.v3.i1.p56


Harvard Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci (2013) Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Vet J, 3 (1), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56


Turabian Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. 2013. Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Veterinary Journal, 3 (1), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56


Chicago Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. "Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats." Open Veterinary Journal 3 (2013), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56


MLA (The Modern Language Association) Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci. "Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats." Open Veterinary Journal 3.1 (2013), 56-63. Print. doi:10.5455/OVJ.2013.v3.i1.p56


APA (American Psychological Association) Style

L.A. Denzoin Vulcano,, O. Confalonieri, R. Franci, M.O. Tapia and A.L. Soraci (2013) Efficacy of free glutathione and niosomal glutathione in the treatment of acetaminophen-induced hepatotoxicity in cats. Open Veterinary Journal, 3 (1), 56-63. doi:10.5455/OVJ.2013.v3.i1.p56


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