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Research Article


A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat

Ahmad Saleh Harahap, Asep Gunawan, Sumiati Sumiati, Isyana Khaerunnisa, Zakiah Wulandari, Cece Sumantri.


Abstract
Background:
Fatty acid-binding protein 4 (FABP4) is involved in the regulation of fatty acid metabolism and fat deposition in chickens by facilitating fatty acid binding and transport within adipocytes.

Aim:
This study evaluated the impact of single-nucleotide polymorphism (SNP) c.266A>G in the FABP4 gene and diets containing lemuru fish oil as a substitute for crude palm oil, as well as zinc and chromium supplements, on the fatty acid profiles of IPB D1 chicken meat.

Methods:
A total of 100 IPB D1 chickens were assigned to four dietary treatments: P0 (control diet), P1 (P0 + Zinc [Zn] and Chromium [Cr]), P2 (P0 + lemuru fish oil), and P3 (P2 + Zn and Cr). Genotypes were identified using DNA sequencing, and a factorial design with complete randomization was used for analyses.

Results:
FABP4 gene polymorphism in chickens was found at SNP c.266A>G. The results showed that the SNP c.266A>G and dietary treatment significantly affected (p < 0.05) the fatty acid composition of the IPB D1 chicken thigh meat. The fatty acid ratio and polyunsaturated fatty acids, such as omega-3 and omega-9, were dramatically affected (p < 0.05) by the interaction between SNP c.266A>G and the applied dietary treatment. The AG genotype chickens fed a diet containing 3% lemuru fish oil supplemented with 120 ppm Zn and 400 ppb Cr showed the lowest omega-6/omega-3 ratio. P3AG (diet treatment containing 3% lemuru fish oil with supplementation of 120 ppm Zn and 400 ppb Cr with genotype AG) had a more balanced fatty acid profile, with a ratio of <10, which is considered beneficial for human health.

Conclusion:
The combination of lemuru fish oil with Zn and Cr (P3) supplementation with the AG genotype improved the fatty acid content of chicken meat, particularly in increasing the omega-3 (EPA and DHA) content and n6/n3 ratio of IPB D1 chickens.

Key words: FABP4 gene; IPB D1 chicken; Lemuru fish oil; Meat quality.


 
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How to Cite this Article
Pubmed Style

Harahap AS, Gunawan A, Sumiati S, Khaerunnisa I, Wulandari Z, Sumantri C. A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat. Open Vet. J.. 2026; 16(9): 6007-6016. doi:10.5455/OVJ.2026.v16.i9.10

Web Style

Harahap AS, Gunawan A, Sumiati S, Khaerunnisa I, Wulandari Z, Sumantri C. A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat. https://www.openveterinaryjournal.com/?mno=306128 [Access: September 01, 2026]. doi:10.5455/OVJ.2026.v16.i9.10

AMA (American Medical Association) Style

Harahap AS, Gunawan A, Sumiati S, Khaerunnisa I, Wulandari Z, Sumantri C. A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat. Open Vet. J.. 2026; 16(9): 6007-6016. doi:10.5455/OVJ.2026.v16.i9.10


Vancouver/ICMJE Style

Harahap AS, Gunawan A, Sumiati S, Khaerunnisa I, Wulandari Z, Sumantri C. A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat. Open Vet. J.. (2026), [cited September 01, 2026]; 16(9): 6007-6016. doi:10.5455/OVJ.2026.v16.i9.10


Harvard Style

Harahap, A. S., Gunawan, . A., Sumiati, . S., Khaerunnisa, . I., Wulandari, . Z. & Sumantri, . C. (2026) A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat. Open Vet. J., 16 (9), 6007-6016. doi:10.5455/OVJ.2026.v16.i9.10


Turabian Style

Harahap, Ahmad Saleh, Asep Gunawan, Sumiati Sumiati, Isyana Khaerunnisa, Zakiah Wulandari, and Cece Sumantri. 2026. A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat. Open Veterinary Journal, 16 (9), 6007-6016. doi:10.5455/OVJ.2026.v16.i9.10


Chicago Style

Harahap, Ahmad Saleh, Asep Gunawan, Sumiati Sumiati, Isyana Khaerunnisa, Zakiah Wulandari, and Cece Sumantri. "A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat." Open Veterinary Journal 16 (2026), 6007-6016. doi:10.5455/OVJ.2026.v16.i9.10


MLA (The Modern Language Association) Style

Harahap, Ahmad Saleh, Asep Gunawan, Sumiati Sumiati, Isyana Khaerunnisa, Zakiah Wulandari, and Cece Sumantri. "A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat." Open Veterinary Journal 16.9 (2026), 6007-6016. Print. doi:10.5455/OVJ.2026.v16.i9.10


APA (American Psychological Association) Style

Harahap, A. S., Gunawan, . A., Sumiati, . S., Khaerunnisa, . I., Wulandari, . Z. & Sumantri, . C. (2026) A nutrigenomics study on the interaction of FABP4 c.266A>G genotypes and diets on fatty acid composition in IPB D1 chicken meat. Open Veterinary Journal, 16 (9), 6007-6016. doi:10.5455/OVJ.2026.v16.i9.10


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