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Original Article


Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?

Ignacio Manuel Espieira, Patricia Noemi Vidal, Mara Carolina Ghersevich, Elber Soler Arias, Fernanda Bosetti, Mara Fernanda Cabrera Blatter, Diego Daniel Miceli, Victor Alejandro Castillo.


Cited By:3

Abstract
Background: The expression and overexpression of luteinizing hormone receptor in the canine adrenal gland cortex has been reported. Therefore, it was hypothesized that a luteinizing hormone (LH)-dependent form of Cushing's syndrome (CS) could exist in dogs.
Aim: Assess whether the adrenal gland post ovariectomy exhibits greater response to ACTH stimulation. Evaluate whether the adrenal gland responds to hCG stimulation by increasing the release of cortisol. Consider whether hCG stimulus testing would be useful as a diagnosis for possible cases of LH-dependent Cushing’s syndrome
Methods: Cortisol concentrations were measured from healthy female dogs (n=16) at baseline and following ACTH stimulation before and 2 months after gonadectomy (OVx). Cortisol concentrations were also measured from female dogs with CS (n=14) following administration of hCG (5000 IU). A post-hCG cortisol concentration of greater than140 nmol/L was used to define dogs with LH-dependent Cushing's syndrome.
Results: In normal female dogs, both pre- and post-stimulation cortisol concentrations increased following OVx (P=0.002 and P=0.0003, respectively). In female dogs with CS, cortisol concentrations increased following stimulation with hCG in 57% (8/14; P=0.002). Age at the time of OVx was associated (P=0.015) with the cortisol response to hCG (8 [5-9] years vs. 3.5 [2-6] years, P=0.0013).
Conclusion: Based on these results, a LH-dependent form of CS occurs in spayed female dogs and that it is more likely to occur when female dogs are spayed later in life

Key words: aberrant receptors, Cushing's syndrome, gonadectomy, hCG, luteinizing hormone


 
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How to Cite this Article
Pubmed Style

Espieira IM, Vidal PN, Ghersevich MC, Arias ES, Bosetti F, Blatter MFC, Miceli DD, Castillo VA, . Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?. Open Vet J. 2021; 11(2): 319-329. doi:10.5455/OVJ.2021.v11.i2.17

Web Style

Espieira IM, Vidal PN, Ghersevich MC, Arias ES, Bosetti F, Blatter MFC, Miceli DD, Castillo VA, . Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?. https://www.openveterinaryjournal.com/?mno=44689 [Access: April 21, 2024]. doi:10.5455/OVJ.2021.v11.i2.17

AMA (American Medical Association) Style

Espieira IM, Vidal PN, Ghersevich MC, Arias ES, Bosetti F, Blatter MFC, Miceli DD, Castillo VA, . Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?. Open Vet J. 2021; 11(2): 319-329. doi:10.5455/OVJ.2021.v11.i2.17


Vancouver/ICMJE Style

Espieira IM, Vidal PN, Ghersevich MC, Arias ES, Bosetti F, Blatter MFC, Miceli DD, Castillo VA, . Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?. Open Vet J. (2021), [cited April 21, 2024]; 11(2): 319-329. doi:10.5455/OVJ.2021.v11.i2.17


Harvard Style

Espieira, I. M., Vidal, P. N., Ghersevich, M. C., Arias, E. S., Bosetti, F., Blatter, M. F. C., Miceli, D. D., Castillo, V. A. & (2021) Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?. Open Vet J, 11 (2), 319-329. doi:10.5455/OVJ.2021.v11.i2.17


Turabian Style

Espieira, Ignacio Manuel, Patricia Noemi Vidal, Mara Carolina Ghersevich, Elber Soler Arias, Fernanda Bosetti, Mara Fernanda Cabrera Blatter, Diego Daniel Miceli, Victor Alejandro Castillo, and . 2021. Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?. Open Veterinary Journal, 11 (2), 319-329. doi:10.5455/OVJ.2021.v11.i2.17


Chicago Style

Espieira, Ignacio Manuel, Patricia Noemi Vidal, Mara Carolina Ghersevich, Elber Soler Arias, Fernanda Bosetti, Mara Fernanda Cabrera Blatter, Diego Daniel Miceli, Victor Alejandro Castillo, and . "Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?." Open Veterinary Journal 11 (2021), 319-329. doi:10.5455/OVJ.2021.v11.i2.17


MLA (The Modern Language Association) Style

Espieira, Ignacio Manuel, Patricia Noemi Vidal, Mara Carolina Ghersevich, Elber Soler Arias, Fernanda Bosetti, Mara Fernanda Cabrera Blatter, Diego Daniel Miceli, Victor Alejandro Castillo, and . "Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?." Open Veterinary Journal 11.2 (2021), 319-329. Print. doi:10.5455/OVJ.2021.v11.i2.17


APA (American Psychological Association) Style

Espieira, I. M., Vidal, P. N., Ghersevich, M. C., Arias, E. S., Bosetti, F., Blatter, M. F. C., Miceli, D. D., Castillo, V. A. & (2021) Adrenal cortex stimulation with hCG in spayed female dogs with Cushing’s syndrome: Is the LH-dependent variant possible?. Open Veterinary Journal, 11 (2), 319-329. doi:10.5455/OVJ.2021.v11.i2.17


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