E-ISSN 2218-6050 | ISSN 2226-4485
 

Research Article


Evaluation of renal disturbance in animal models of polycystic ovary syndrome

Yudit Oktanella, Handayu Untari, Dyah Kinasih Wuragil, Galuh Chandra Agustina, Dyah Ayu Oktavianie Pratama.


Abstract
Background:
Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by hyperandrogenism, hyperinsulinemia, followed by luteinizing hormone (LH) and follicle stimulating hormone (FSH) deficiency. PCOS conditions cause metabolic disorders that increase uric acid levels and malondialdehyde levels. Animal models of PCOS have been used extensively in research to study the pathogenesis, clinical characteristics and treatment of PCOS.
Aim:
This study aimed to identify the pathological mechanisms underlying renal dysfunction in PCOS by observing several parameters, including BUN, creatinine, uric acid, and renal MDA levels.
Methods:
This research was an experimental designed study using Wistar rat (Rattus norvegicus) as animal model of PCOS which were divided into three groups: negative control (CN) group (n=6), Testosterone propionate induction group (n=6), and estradiol valerate induction group (n=6).
Results:
According to statistical analysis it indicated that induction of TP and EV can increase blood uric acid levels in PCOS model rats (p<0.05), TP induction can increase kidney BUN and MDA levels significantly (p<0.05), However, the observation of creatinine levels did not show significant differences in all treatment groups (p>0.05).
Conclusion:
Based on the results of this study, it can be concluded that the induction of animal models with testosterone propionate can trigger a significant renal damage compared to estradiol valerate.

Key words: PCOS, Animal model, Renal disturbance, Testosterone propionate, Estradiol valerate


 
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How to Cite this Article
Pubmed Style

Oktanella Y, Untari H, Wuragil DK, Agustina GC, Pratama DAO. Evaluation of renal disturbance in animal models of polycystic ovary syndrome. Open Vet J. 2023; 13(8): 1003-1011. doi:10.5455/OVJ.2023.v13.i8.6


Web Style

Oktanella Y, Untari H, Wuragil DK, Agustina GC, Pratama DAO. Evaluation of renal disturbance in animal models of polycystic ovary syndrome. https://www.openveterinaryjournal.com/?mno=158814 [Access: April 10, 2024]. doi:10.5455/OVJ.2023.v13.i8.6


AMA (American Medical Association) Style

Oktanella Y, Untari H, Wuragil DK, Agustina GC, Pratama DAO. Evaluation of renal disturbance in animal models of polycystic ovary syndrome. Open Vet J. 2023; 13(8): 1003-1011. doi:10.5455/OVJ.2023.v13.i8.6



Vancouver/ICMJE Style

Oktanella Y, Untari H, Wuragil DK, Agustina GC, Pratama DAO. Evaluation of renal disturbance in animal models of polycystic ovary syndrome. Open Vet J. (2023), [cited April 10, 2024]; 13(8): 1003-1011. doi:10.5455/OVJ.2023.v13.i8.6



Harvard Style

Oktanella, Y., Untari, . H., Wuragil, . D. K., Agustina, . G. C. & Pratama, . D. A. O. (2023) Evaluation of renal disturbance in animal models of polycystic ovary syndrome. Open Vet J, 13 (8), 1003-1011. doi:10.5455/OVJ.2023.v13.i8.6



Turabian Style

Oktanella, Yudit, Handayu Untari, Dyah Kinasih Wuragil, Galuh Chandra Agustina, and Dyah Ayu Oktavianie Pratama. 2023. Evaluation of renal disturbance in animal models of polycystic ovary syndrome. Open Veterinary Journal, 13 (8), 1003-1011. doi:10.5455/OVJ.2023.v13.i8.6



Chicago Style

Oktanella, Yudit, Handayu Untari, Dyah Kinasih Wuragil, Galuh Chandra Agustina, and Dyah Ayu Oktavianie Pratama. "Evaluation of renal disturbance in animal models of polycystic ovary syndrome." Open Veterinary Journal 13 (2023), 1003-1011. doi:10.5455/OVJ.2023.v13.i8.6



MLA (The Modern Language Association) Style

Oktanella, Yudit, Handayu Untari, Dyah Kinasih Wuragil, Galuh Chandra Agustina, and Dyah Ayu Oktavianie Pratama. "Evaluation of renal disturbance in animal models of polycystic ovary syndrome." Open Veterinary Journal 13.8 (2023), 1003-1011. Print. doi:10.5455/OVJ.2023.v13.i8.6



APA (American Psychological Association) Style

Oktanella, Y., Untari, . H., Wuragil, . D. K., Agustina, . G. C. & Pratama, . D. A. O. (2023) Evaluation of renal disturbance in animal models of polycystic ovary syndrome. Open Veterinary Journal, 13 (8), 1003-1011. doi:10.5455/OVJ.2023.v13.i8.6