E-ISSN 2218-6050 | ISSN 2226-4485
 
2024, Vol: 14, Issue: 10
14 / 10Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submission Form

Research Article


The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus

Amal A.M. Eid, Ali M. Mahmoud, Esraa E. Hamouda, Mohamed A. Metwally, Rasha M.M. Ezz-Eldin, Reham M. ElBakrey.


Abstract
Background:
Being a ubiquitous, highly contagious virus with a continuous mutation and a large number of evolutions worldwide, the infectious bronchitis virus (IBV) continues to wreak problems among Egyptian chickens and generate economic losses. The commonly applied IBV vaccination protocols in broilers include alternatives to classic and/or variant attenuated live virus vaccines.
Aim:
The current study targeted to assess the protective efficacy of concurrent and successive Ma5 and 4/91 vaccine strain regimens against the field variant II IBV strain (IBV-EGY-ZU/Ck-127/2021) in chickens.
Methods:
Commercial broiler chickens were vaccinated with Ma5 and 4/91 strains simultaneously at 1 and 14 days of age. The evaluation parameters included clinical protection and humoral and early innate immunity aspects in the renal tissues of vaccinated and infected birds.
Results:
The vaccine regimen ameliorated the clinical and histopathological lesions against variant II IBV and enhanced body gain as well as it succeeded in preventing tracheal shedding and minimizing cloacal shedding of the field virus. The IL-1β mRNA gene expression was evident as early as 24 hours, with highly significant upregulation at 48 hours post-vaccination and 24 hours post-challenge in vaccinated birds. Remarkable upregulation was observed in OAS expression 48 hours post-challenge in vaccinated and unvaccinated infected birds. The vaccinated birds developed a significant antibody titer of 704.0±111.98 at 28 days of age, with a consistent antibody titer increase after the challenge.
Conclusion:
Overall, a combination of heterologous protectotype commercial vaccines achieved good protection against the Egyptian variant II IBV strain. This vaccine program could be an effective protocol against the threat posed by IBV viruses circulating in the Egyptian field.

Key words: Infectious bronchitis virus (IBV), Variant II, Vaccine efficacy, Pathology, Immunity


 
ARTICLE TOOLS
Abstract
PDF Fulltext
HTML Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Amal A.M. Eid
Articles by Ali M. Mahmoud
Articles by Esraa E. Hamouda
Articles by Mohamed A. Metwally
Articles by Rasha M.M. Ezz-Eldin
Articles by Reham M. ElBakrey
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Eid AA, Mahmoud AM, Hamouda EE, Metwally MA, Ezz-Eldin RM, ElBakrey RM. The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 90-107. doi:10.5455/OVJ.2024.v14.i1.9

Web Style

Eid AA, Mahmoud AM, Hamouda EE, Metwally MA, Ezz-Eldin RM, ElBakrey RM. The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus. https://www.openveterinaryjournal.com/?mno=175112 [Access: November 08, 2024]. doi:10.5455/OVJ.2024.v14.i1.9

AMA (American Medical Association) Style

Eid AA, Mahmoud AM, Hamouda EE, Metwally MA, Ezz-Eldin RM, ElBakrey RM. The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 90-107. doi:10.5455/OVJ.2024.v14.i1.9


Vancouver/ICMJE Style

Eid AA, Mahmoud AM, Hamouda EE, Metwally MA, Ezz-Eldin RM, ElBakrey RM. The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus. Open Vet J. (2024), [cited November 08, 2024]; 14((1) (Zagazig Veterinary Conference)): 90-107. doi:10.5455/OVJ.2024.v14.i1.9


Harvard Style

Eid, A. A., Mahmoud, . A. M., Hamouda, . E. E., Metwally, . M. A., Ezz-Eldin, . R. M. & ElBakrey, . R. M. (2024) The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus. Open Vet J, 14 ((1) (Zagazig Veterinary Conference)), 90-107. doi:10.5455/OVJ.2024.v14.i1.9


Turabian Style

Eid, Amal A.M., Ali M. Mahmoud, Esraa E. Hamouda, Mohamed A. Metwally, Rasha M.M. Ezz-Eldin, and Reham M. ElBakrey. 2024. The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 90-107. doi:10.5455/OVJ.2024.v14.i1.9


Chicago Style

Eid, Amal A.M., Ali M. Mahmoud, Esraa E. Hamouda, Mohamed A. Metwally, Rasha M.M. Ezz-Eldin, and Reham M. ElBakrey. "The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus." Open Veterinary Journal 14 (2024), 90-107. doi:10.5455/OVJ.2024.v14.i1.9


MLA (The Modern Language Association) Style

Eid, Amal A.M., Ali M. Mahmoud, Esraa E. Hamouda, Mohamed A. Metwally, Rasha M.M. Ezz-Eldin, and Reham M. ElBakrey. "The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus." Open Veterinary Journal 14.(1) (Zagazig Veterinary Conference) (2024), 90-107. Print. doi:10.5455/OVJ.2024.v14.i1.9


APA (American Psychological Association) Style

Eid, A. A., Mahmoud, . A. M., Hamouda, . E. E., Metwally, . M. A., Ezz-Eldin, . R. M. & ElBakrey, . R. M. (2024) The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 90-107. doi:10.5455/OVJ.2024.v14.i1.9


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldagpublisher.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly