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Case Report


A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings

Gabriela Fernandes Silva, Tiago Esteves Ribeiro, Raquel Cunha, Patricia Becerra Salas, Tiago Guimarães, Mário Ribeiro, Gonçalo Barros, Fátima Carvalho, João Rodrigo Mesquita, Irina Amorim.


Abstract
Background:
Although relatively uncommon, lymphoma is the most prevalent haematopoietic neoplasia in horses, and multicentric lymphoma remains the most common presentation of the disease. The pathogenesis of equine lymphoma is still poorly understood and the diagnosis is usually confirmed at an advanced stage of the disease, compromising the prognosis. This study investigated the clinical, pathological and molecular features of a case of equine multicentric lymphoma.
Case Description:
An apparently healthy 5-year-old crossbreed mare hospitalized at Centre of Animal Reproduction of Vairão (CRAV), Portugal, suddenly presented clinical signs of supraorbital oedema and mandibular lymph node enlargement, developing fever, facial oedema and generalized lymphadenopathy. The mare ended up dying twenty-four days after the first clinical signs due to multisystem organ failure. Haematological and biochemical analyses, necropsy and microscopic and molecular evaluation of affected tissues were performed. At necropsy, the main findings were multiple multinodular lesions, distributed along the serous surface of oropharynx, trachea, pericardium, gastrointestinal tract and mesentery. Microscopically, these consisted of solid proliferations of neoplastic round cells that exhibited immunopositivity for CD3 (T cells). Based on these findings, a medium-grade multicentric T-cell lymphoma was diagnosed.
Conclusion:
There is still very little research regarding the molecular characterization of lymphoma in horses. As an entity itself quite heterogeneous, it is important to describe the interspecies particularities to understand its development and behaviour.

Key words: Equine, Horse, Lymphoma, Multicentric, T-cell


 
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How to Cite this Article
Pubmed Style

Silva GF, Ribeiro TE, Cunha R, Salas PB, Guimarães T, Ribeiro M, Barros G, FC, Mesquita JR, Amorim I. A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings. Open Vet J. 2024; 14(5): 1294-1301. doi:10.5455/OVJ.2024.v14.i5.24


Web Style

Silva GF, Ribeiro TE, Cunha R, Salas PB, Guimarães T, Ribeiro M, Barros G, FC, Mesquita JR, Amorim I. A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings. https://www.openveterinaryjournal.com/?mno=176520 [Access: June 03, 2024]. doi:10.5455/OVJ.2024.v14.i5.24


AMA (American Medical Association) Style

Silva GF, Ribeiro TE, Cunha R, Salas PB, Guimarães T, Ribeiro M, Barros G, FC, Mesquita JR, Amorim I. A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings. Open Vet J. 2024; 14(5): 1294-1301. doi:10.5455/OVJ.2024.v14.i5.24



Vancouver/ICMJE Style

Silva GF, Ribeiro TE, Cunha R, Salas PB, Guimarães T, Ribeiro M, Barros G, FC, Mesquita JR, Amorim I. A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings. Open Vet J. (2024), [cited June 03, 2024]; 14(5): 1294-1301. doi:10.5455/OVJ.2024.v14.i5.24



Harvard Style

Silva, G. F., Ribeiro, . T. E., Cunha, . R., Salas, . P. B., Guimarães, . T., Ribeiro, . M., Barros, . G., , . F. C., Mesquita, . J. R. & Amorim, . I. (2024) A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings. Open Vet J, 14 (5), 1294-1301. doi:10.5455/OVJ.2024.v14.i5.24



Turabian Style

Silva, Gabriela Fernandes, Tiago Esteves Ribeiro, Raquel Cunha, Patricia Becerra Salas, Tiago Guimarães, Mário Ribeiro, Goncalo Barros, Fátima Carvalho, João Rodrigo Mesquita, and Irina Amorim. 2024. A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings. Open Veterinary Journal, 14 (5), 1294-1301. doi:10.5455/OVJ.2024.v14.i5.24



Chicago Style

Silva, Gabriela Fernandes, Tiago Esteves Ribeiro, Raquel Cunha, Patricia Becerra Salas, Tiago Guimarães, Mário Ribeiro, Goncalo Barros, Fátima Carvalho, João Rodrigo Mesquita, and Irina Amorim. "A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings." Open Veterinary Journal 14 (2024), 1294-1301. doi:10.5455/OVJ.2024.v14.i5.24



MLA (The Modern Language Association) Style

Silva, Gabriela Fernandes, Tiago Esteves Ribeiro, Raquel Cunha, Patricia Becerra Salas, Tiago Guimarães, Mário Ribeiro, Goncalo Barros, Fátima Carvalho, João Rodrigo Mesquita, and Irina Amorim. "A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings." Open Veterinary Journal 14.5 (2024), 1294-1301. Print. doi:10.5455/OVJ.2024.v14.i5.24



APA (American Psychological Association) Style

Silva, G. F., Ribeiro, . T. E., Cunha, . R., Salas, . P. B., Guimarães, . T., Ribeiro, . M., Barros, . G., , . F. C., Mesquita, . J. R. & Amorim, . I. (2024) A case of equine multicentric lymphoma: Clinical, microscopical and molecular findings. Open Veterinary Journal, 14 (5), 1294-1301. doi:10.5455/OVJ.2024.v14.i5.24