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2025, Vol: 15, Issue: 2
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Research Article


How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?

Kittara Chanmongkolpanit, Nattapon Riengvirodkij, Phuttipan Channgam, Pemika Kaenchan, Wasana Buayam, Yada Janhirun, Rassameepen Phonarknguen, Mookmanee Tansakul, Walasinee Sakcamduang.


Abstract
Background:
Myxomatous mitral valve disease (MMVD) is prevalent in dogs. Specialized diagnostics (radiography, echocardiography) may be unavailable in some veterinary settings. Cardiac biomarkers offer potential alternatives.
Aim:
This study evaluated diagnostic value of N-terminal fragments of pro-brain natriuretic peptides (NT-proBNPs), atrial natriuretic peptides (ANPs), and cardiac troponin I (cTnI) levels in dogs with MMVD.
Methods:
69 dogs with MMVD (asymptomatic and symptomatic) and 19 healthy controls were assessed. Biomarker levels were measured using commercial kit rapid tests.
Results:
Our results showed that the median NT-proBNP level in the symptomatic group was higher than those in the asymptomatic (P < 0.001) and control (P < 0.001) groups. Moreover, the median NT-proBNP level in the asymptomatic group was higher than that in the control group (P < 0.001). The cTnI level in the control group was lower than those in the asymptomatic (P = 0.039) and symptomatic (P = 0.001) groups. No statistically significant difference in the cTnI level was noted between the asymptomatic and symptomatic groups. The best cutoff value of the NT-proBNP level to differentiate the normal controls from dogs with MMVD with or without congestive heart failure was > 505.65 pmol/L (sensitivity, 76.8%; specificity, 89.5%; and area under the curve [AUC], 0.862). The suggested cutoff value of the NT-proBNP level to differentiate symptomatic MMVD from asymptomatic MMVD was >787.65 pmol/L (sensitivity, 78.38%; specificity, 72.55%; and AUC, 0.792).
Conclusion:
NT-proBNP and cTnI may serve as point-of-care tests for dyspneic dogs, aiding MMVD assessment where specialized diagnostics are limited.

Key words: Myxomatous mitral valve disease, Cardiac disease, Canine, Dog, Biomarker


 
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How to Cite this Article
Pubmed Style

Chanmongkolpanit K, Riengvirodkij N, Channgam P, Kaenchan P, Buayam W, Janhirun Y, Phonarknguen R, Tansakul M, Sakcamduang W. How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?. Open Vet J. 2024; 14(6): 1426-1441. doi:10.5455/OVJ.2024.v14.i6.10

Web Style

Chanmongkolpanit K, Riengvirodkij N, Channgam P, Kaenchan P, Buayam W, Janhirun Y, Phonarknguen R, Tansakul M, Sakcamduang W. How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?. https://www.openveterinaryjournal.com/?mno=193986 [Access: March 19, 2025]. doi:10.5455/OVJ.2024.v14.i6.10

AMA (American Medical Association) Style

Chanmongkolpanit K, Riengvirodkij N, Channgam P, Kaenchan P, Buayam W, Janhirun Y, Phonarknguen R, Tansakul M, Sakcamduang W. How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?. Open Vet J. 2024; 14(6): 1426-1441. doi:10.5455/OVJ.2024.v14.i6.10


Vancouver/ICMJE Style

Chanmongkolpanit K, Riengvirodkij N, Channgam P, Kaenchan P, Buayam W, Janhirun Y, Phonarknguen R, Tansakul M, Sakcamduang W. How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?. Open Vet J. (2024), [cited March 19, 2025]; 14(6): 1426-1441. doi:10.5455/OVJ.2024.v14.i6.10


Harvard Style

Chanmongkolpanit, K., Riengvirodkij, . N., Channgam, . P., Kaenchan, . P., Buayam, . W., Janhirun, . Y., Phonarknguen, . R., Tansakul, . M. & Sakcamduang, . W. (2024) How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?. Open Vet J, 14 (6), 1426-1441. doi:10.5455/OVJ.2024.v14.i6.10


Turabian Style

Chanmongkolpanit, Kittara, Nattapon Riengvirodkij, Phuttipan Channgam, Pemika Kaenchan, Wasana Buayam, Yada Janhirun, Rassameepen Phonarknguen, Mookmanee Tansakul, and Walasinee Sakcamduang. 2024. How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?. Open Veterinary Journal, 14 (6), 1426-1441. doi:10.5455/OVJ.2024.v14.i6.10


Chicago Style

Chanmongkolpanit, Kittara, Nattapon Riengvirodkij, Phuttipan Channgam, Pemika Kaenchan, Wasana Buayam, Yada Janhirun, Rassameepen Phonarknguen, Mookmanee Tansakul, and Walasinee Sakcamduang. "How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?." Open Veterinary Journal 14 (2024), 1426-1441. doi:10.5455/OVJ.2024.v14.i6.10


MLA (The Modern Language Association) Style

Chanmongkolpanit, Kittara, Nattapon Riengvirodkij, Phuttipan Channgam, Pemika Kaenchan, Wasana Buayam, Yada Janhirun, Rassameepen Phonarknguen, Mookmanee Tansakul, and Walasinee Sakcamduang. "How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?." Open Veterinary Journal 14.6 (2024), 1426-1441. Print. doi:10.5455/OVJ.2024.v14.i6.10


APA (American Psychological Association) Style

Chanmongkolpanit, K., Riengvirodkij, . N., Channgam, . P., Kaenchan, . P., Buayam, . W., Janhirun, . Y., Phonarknguen, . R., Tansakul, . M. & Sakcamduang, . W. (2024) How accurate are NT-proBNP, ANP, and cTnI levels in diagnosing dogs with myxomatous mitral valve disease?. Open Veterinary Journal, 14 (6), 1426-1441. doi:10.5455/OVJ.2024.v14.i6.10


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