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Research Article


In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats

Jamela K. Abd-Alhussien, Masar J. Al-Kurdy, Suha A. Hussein.


Abstract
Background:
The most widespread conditions that affected on primarily male population is Benign hyperplasia of the prostate BPH. Flax seeds has been reported to antiproliferation properties and exhibit antitumor.
Aim:
We assessed the impact of Flax seeds ethanolic excerpt on BPH within testosterone propionate induced model of rats.
Methods:
A pre-3-week daily injection of testosterone propionate (3 mg/kg BW) was used to induce BPH. Twenty male rats (200-240 gm) were randomly divided to 4 equal groups (n=5) negative Group under control was given PBS orally, corn oil S/C, BPH induced rats received 3mg/kg BW TP for 3 weeks, extract group received 50 mg/Kg extract twice daily for 2 weeks Finasteride group received standard drug 10 mg/Kg BW for 2 weeks. When the course of treatment is over, rats were sacrificed and the blood was collected and separated, the prostate of the rats were harvested for histological examination.
Results:
The results showed that flax seeds ethanolic extract could significantly (P<0.05) reduce the prostate gland weight, prostate index, serum level of PAS, testosterone,5-a reductase enzyme in BPH induced rats and improved the tissue morphology of the prostate.
Conclusion:
Based on our results, extract suggested that have promising role for the treatment of benign hyperplasia of the prostate.

Key words: Finasteride, Flax seeds, Prostatic hyperplasia, Testosterone, Tissue morphology


 
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How to Cite this Article
Pubmed Style

Abd-Alhussien JK, Al-Kurdy MJ, Hussein SA. In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. Open Vet J. 2024; 14(8): 1928-1935. doi:10.5455/OVJ.2024.v14.i8.21

Web Style

Abd-Alhussien JK, Al-Kurdy MJ, Hussein SA. In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. https://www.openveterinaryjournal.com/?mno=200828 [Access: November 07, 2024]. doi:10.5455/OVJ.2024.v14.i8.21

AMA (American Medical Association) Style

Abd-Alhussien JK, Al-Kurdy MJ, Hussein SA. In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. Open Vet J. 2024; 14(8): 1928-1935. doi:10.5455/OVJ.2024.v14.i8.21


Vancouver/ICMJE Style

Abd-Alhussien JK, Al-Kurdy MJ, Hussein SA. In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. Open Vet J. (2024), [cited November 07, 2024]; 14(8): 1928-1935. doi:10.5455/OVJ.2024.v14.i8.21


Harvard Style

Abd-Alhussien, J. K., Al-Kurdy, . M. J. & Hussein, . S. A. (2024) In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. Open Vet J, 14 (8), 1928-1935. doi:10.5455/OVJ.2024.v14.i8.21


Turabian Style

Abd-Alhussien, Jamela K., Masar J. Al-Kurdy, and Suha A. Hussein. 2024. In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. Open Veterinary Journal, 14 (8), 1928-1935. doi:10.5455/OVJ.2024.v14.i8.21


Chicago Style

Abd-Alhussien, Jamela K., Masar J. Al-Kurdy, and Suha A. Hussein. "In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats." Open Veterinary Journal 14 (2024), 1928-1935. doi:10.5455/OVJ.2024.v14.i8.21


MLA (The Modern Language Association) Style

Abd-Alhussien, Jamela K., Masar J. Al-Kurdy, and Suha A. Hussein. "In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats." Open Veterinary Journal 14.8 (2024), 1928-1935. Print. doi:10.5455/OVJ.2024.v14.i8.21


APA (American Psychological Association) Style

Abd-Alhussien, J. K., Al-Kurdy, . M. J. & Hussein, . S. A. (2024) In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats. Open Veterinary Journal, 14 (8), 1928-1935. doi:10.5455/OVJ.2024.v14.i8.21


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