E-ISSN 2218-6050 | ISSN 2226-4485
 
2025, Vol: 15, Issue: 8
15 / 8Current Issue ArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

OVJ Manuscript Submissio Form

Research Article


Sedative effects of detomidine and midazolam combination in horses

Érika Ribeiro Gomes, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares, João Vitor Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, Marcos Ferrante.


Abstract
Background:
The combination of detomidine and midazolam may provide safer sedation with muscle-relaxant effects, which is particularly necessary during standing procedures.

Aim:
Thus, the objective of this study was to evaluate the sedative and muscle-relaxant effects of the detomidine-midazolam combination in horses through a pharmacodynamic study.

Methods:
Five horses were used and subjected to four experimental protocols: 15 µg/kg of detomidine (D15); a combination of detomidine (15 µg/kg) with 25 µg/kg (DM25), 50 µg/kg (DM50), or 75 µg/kg (DM75) of midazolam, administered intravenously. Sedative and muscle-relaxant effects, as well as physiological parameters, were evaluated and statistically analyzed.

Results:
All protocols resulted in a decrease in head height, although no significant difference was observed among them. Acoustic stimulus response and tongue tone relaxation showed significant effects in the global analysis.

Conclusion:
This study contributes to the understanding and application of this combination in equine sedation protocols.

Key words: Sedation, α-2 agonists, Benzodiazepines, Chemical restraint


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Érika Ribeiro Gomes
Articles by Larissa Alexsandra Felix
Articles by Lucas Wamser Fonseca Gonzaga
Articles by Naira Fernanda Dias da Silva
Articles by Bruna Christina Fernandes Soares
Articles by João Vitor Fernandes Cotrim de Almeida
Articles by Gabriela Pereira Souza
Articles by Rodrigo Norberto Pereira
Articles by Marilda Onghero Taffarel
Articles by Marcos Ferrante
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Gomes ÃR, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCF, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative effects of detomidine and midazolam combination in horses. Open Vet. J.. 2025; 15(7): 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5

Web Style

Gomes ÃR, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCF, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative effects of detomidine and midazolam combination in horses. https://www.openveterinaryjournal.com/?mno=231218 [Access: August 31, 2025]. doi:10.5455/OVJ.2025.v15.i7.5

AMA (American Medical Association) Style

Gomes ÃR, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCF, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative effects of detomidine and midazolam combination in horses. Open Vet. J.. 2025; 15(7): 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Vancouver/ICMJE Style

Gomes ÃR, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCF, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative effects of detomidine and midazolam combination in horses. Open Vet. J.. (2025), [cited August 31, 2025]; 15(7): 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Harvard Style

Gomes, Ã. R., Felix, . L. A., Gonzaga, . L. W. F., Silva, . N. F. D. D., Soares, . B. C. F., , Souza, . G. P., Pereira, . R. N., Taffarel, . M. O. & Ferrante, . M. (2025) Sedative effects of detomidine and midazolam combination in horses. Open Vet. J., 15 (7), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Turabian Style

Gomes, Érika Ribeiro, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares, João Vitor Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, and Marcos Ferrante. 2025. Sedative effects of detomidine and midazolam combination in horses. Open Veterinary Journal, 15 (7), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Chicago Style

Gomes, Érika Ribeiro, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares, João Vitor Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, and Marcos Ferrante. "Sedative effects of detomidine and midazolam combination in horses." Open Veterinary Journal 15 (2025), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


MLA (The Modern Language Association) Style

Gomes, Érika Ribeiro, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares, João Vitor Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, and Marcos Ferrante. "Sedative effects of detomidine and midazolam combination in horses." Open Veterinary Journal 15.7 (2025), 2938-2947. Print. doi:10.5455/OVJ.2025.v15.i7.5


APA (American Psychological Association) Style

Gomes, Ã. R., Felix, . L. A., Gonzaga, . L. W. F., Silva, . N. F. D. D., Soares, . B. C. F., , Souza, . G. P., Pereira, . R. N., Taffarel, . M. O. & Ferrante, . M. (2025) Sedative effects of detomidine and midazolam combination in horses. Open Veterinary Journal, 15 (7), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Author LoginReviewer LoginAbout PublisherPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyTerms of UseLicense InformationCopyright Information

About Open Veterinary Journal

Open Veterinary Journal provides a fast track coupled with high quality peer review process for original research articles, review articles, short communi ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information

All correspondence should be addressed to:

Prof. Ibrahim Eldaghayes: Owner, Founder and Editor-in-Chief

Open Veterinary Journal


Faculty of Veterinary Medicine, University of Tripoli

P.O. Box 13662, Tripoli, Libya

and


Eldaghayes Publisher

www.eldaghayes.com 

Email: ibrahim.eldaghayes@vetmed.edu.ly