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Research Article 


Sedative Effects of the Combination of Detomidine and Midazolam In Horses

Erika Ribeiro Gomes, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares Soares, João Vitor Fernandes Cotrim Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, Marcos Ferrante.


Abstract
Background: The combination of detomidine and midazolam may provide safer sedation with muscle-relaxant effects, which is particularly necessary during standing procedures.
Aim: Thus, the objective of this study was to evaluate the sedative and muscle-relaxant effects of the detomidine-midazolam combination in horses through a pharmacodynamic study.
Methods: Five horses were used and subjected to four experimental protocols: 15 µg/kg of detomidine (D15); a combination of detomidine (15 µg/kg) with 25 µg/kg (DM25), 50 µg/kg (DM50), or 75 µg/kg (DM75) of midazolam, administered intravenously. Sedative and muscle-relaxant effects, as well as physiological parameters, were evaluated and statistically analyzed.
Results: All protocols resulted in a decrease in head height, although no significant difference was observed among them. Acoustic stimulus response and tongue tone relaxation showed significant effects in the global analysis.
Conclusion: This study contributes to the understanding and application of this combination in equine sedation protocols.

Key words: sedation, α-2 agonists, benzodiazepines, chemical restraint


 
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How to Cite this Article
Pubmed Style

Gomes ER, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCFS, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative Effects of the Combination of Detomidine and Midazolam In Horses. Open Vet J. 2025; 15(7): 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5

Web Style

Gomes ER, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCFS, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative Effects of the Combination of Detomidine and Midazolam In Horses. https://www.openveterinaryjournal.com/?mno=231218 [Access: August 08, 2025]. doi:10.5455/OVJ.2025.v15.i7.5

AMA (American Medical Association) Style

Gomes ER, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCFS, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative Effects of the Combination of Detomidine and Midazolam In Horses. Open Vet J. 2025; 15(7): 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Vancouver/ICMJE Style

Gomes ER, Felix LA, Gonzaga LWF, Silva NFDD, Soares BCFS, , Souza GP, Pereira RN, Taffarel MO, Ferrante M. Sedative Effects of the Combination of Detomidine and Midazolam In Horses. Open Vet J. (2025), [cited August 08, 2025]; 15(7): 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Harvard Style

Gomes, E. R., Felix, . L. A., Gonzaga, . L. W. F., Silva, . N. F. D. D., Soares, . B. C. F. S., , Souza, . G. P., Pereira, . R. N., Taffarel, . M. O. & Ferrante, . M. (2025) Sedative Effects of the Combination of Detomidine and Midazolam In Horses. Open Vet J, 15 (7), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Turabian Style

Gomes, Erika Ribeiro, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares Soares, João Vitor Fernandes Cotrim Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, and Marcos Ferrante. 2025. Sedative Effects of the Combination of Detomidine and Midazolam In Horses. Open Veterinary Journal, 15 (7), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


Chicago Style

Gomes, Erika Ribeiro, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares Soares, João Vitor Fernandes Cotrim Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, and Marcos Ferrante. "Sedative Effects of the Combination of Detomidine and Midazolam In Horses." Open Veterinary Journal 15 (2025), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


MLA (The Modern Language Association) Style

Gomes, Erika Ribeiro, Larissa Alexsandra Felix, Lucas Wamser Fonseca Gonzaga, Naira Fernanda Dias Da Silva, Bruna Christina Fernandes Soares Soares, João Vitor Fernandes Cotrim Fernandes Cotrim De Almeida, Gabriela Pereira Souza, Rodrigo Norberto Pereira, Marilda Onghero Taffarel, and Marcos Ferrante. "Sedative Effects of the Combination of Detomidine and Midazolam In Horses." Open Veterinary Journal 15.7 (2025), 2938-2947. Print. doi:10.5455/OVJ.2025.v15.i7.5


APA (American Psychological Association) Style

Gomes, E. R., Felix, . L. A., Gonzaga, . L. W. F., Silva, . N. F. D. D., Soares, . B. C. F. S., , Souza, . G. P., Pereira, . R. N., Taffarel, . M. O. & Ferrante, . M. (2025) Sedative Effects of the Combination of Detomidine and Midazolam In Horses. Open Veterinary Journal, 15 (7), 2938-2947. doi:10.5455/OVJ.2025.v15.i7.5


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