E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article

Online Publishing Date:
30 / 06 / 2016



Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal.


Cited By:16

Abstract
The objective of the present study was to compare the effects of isotretinoin 9-cis (RA9-cis) as a post-surgery treatment of thyroid carcinoma to a traditional treatment (doxorubicin) and no treatment. Owners who did not want their dogs to receive treatment were placed into the control group A (GA; n=10). The remaining dogs were randomly placed into either group B (GB; n=12) and received doxorubicin at a dose of 30 mg/m2 every three weeks, for six complete cycles or group C (GC; n=15) and treated with RA9-cis at a dose of 2 mg/kg/day for 6 months. The time of the recurrence was significantly shorter in the GA and GB compared to GC (P=0.0007; P=0.0015 respectively), while we did not detect differences between GA and GB. The hazard ratio of recurrence between GA and GB compared to GC were 7.25 and 5.60 times shorter, respectively. We did not detect any differences between the other groups. The risk ratio of recurrence was 2.0 times higher in GA compared to GC and 2.1 times higher in GB compared to GC. The type of carcinoma had an effect on time of survival with follicular carcinomas having an increased mean survival timethan follicular-compact carcinomas (P<0.0001) and follicular-compact carcinomas had a longer mean survival time than compact carcinomas. The interaction among treatment and type was significant, but survival time in follicular carcinomas did not differ between treatments. In follicular-compact carcinomas the survival time of GC was greater than GB (P<0.05), but we did not detect a difference between GA and GB. In conclusion, this study shows that the use of surgery in combination with RA9-cis treatment significantly increases survival rate and decreases the time to tumor recurrence when compared to doxorubicin treated or untreated dogs. The histological type of carcinoma interacted with treatment for time to recurrence and survival time, with more undifferentiated carcinomas having a worse prognosis than differentiated carcinomas.

Key words: Differentiated follicular carcinoma, Retinoic acid, Thyroid carcinoma, Thyroid tumour


 
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How to Cite this Article
Pubmed Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal. Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome. Open Vet J. 2016; 6(1): 6-14. doi:10.4314/ovj.v6i1.2


Web Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal. Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome. https://www.openveterinaryjournal.com/?mno=234355 [Access: July 13, 2024]. doi:10.4314/ovj.v6i1.2


AMA (American Medical Association) Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal. Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome. Open Vet J. 2016; 6(1): 6-14. doi:10.4314/ovj.v6i1.2



Vancouver/ICMJE Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal. Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome. Open Vet J. (2016), [cited July 13, 2024]; 6(1): 6-14. doi:10.4314/ovj.v6i1.2



Harvard Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal (2016) Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome. Open Vet J, 6 (1), 6-14. doi:10.4314/ovj.v6i1.2



Turabian Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal. 2016. Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome. Open Veterinary Journal, 6 (1), 6-14. doi:10.4314/ovj.v6i1.2



Chicago Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal. "Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome." Open Veterinary Journal 6 (2016), 6-14. doi:10.4314/ovj.v6i1.2



MLA (The Modern Language Association) Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal. "Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome." Open Veterinary Journal 6.1 (2016), 6-14. Print. doi:10.4314/ovj.v6i1.2



APA (American Psychological Association) Style

V. Castillo, P. Pessina, P. Hall, M.F. Cabrera Blatter, D. Miceli, E. Soler Arias, P. Vidal (2016) Post-surgical treatment of thyroid carcinoma in dogs with retinoic acid 9 cis improves patient outcome. Open Veterinary Journal, 6 (1), 6-14. doi:10.4314/ovj.v6i1.2