E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai.


Cited By:8

Abstract
Environmental toxicants such as chemicals, heavy metals, and pesticides have been shown to promote transgenerational inheritance of abnormal phenotypes and/or diseases to multiple subsequent generations following parental and/ or ancestral exposures. This study was designed to examine the potential transgenerational action of the environmental toxicant trichloroethane (TCE) on transmission of liver abnormality, and to elucidate the molecular etiology of hepatocyte cell damage. A total of thirty two healthy immature female albino mice were randomly divided into three equal groups as follows: a sham group, which did not receive any treatment; a vehicle group, which received corn oil alone, and TCE treated group (3 weeks, 100 μg/kg i.p., every 4th day). The F0 and F1 generation control and TCE populations were sacrificed at the age of four months, and various abnormalities histpathologically investigated. Cell death and oxidative stress indices were also measured. The present study provides experimental evidence for the inheritance of environmentally induced liver abnormalities in mice. The results of this study show that exposure to the TCE promoted adult onset liver abnormalities in F0 female mice as well as unexposed F1 generation offspring. It is the first study to report a transgenerational liver abnormality in the F1 generation mice through maternal line prior to gestation. This finding was based on careful evaluation of liver histopathological abnormalities, apoptosis of hepatocytes, and measurements of oxidative stress biomarkers (lipid peroxidation, protein carbonylation, and nitric oxide) in control and TCE populations. There was an increase in liver histopathological abnormalities, cell death, and oxidative lipid damage in F0 and F1 hepatic tissues of TCE treated group. In conclusion, this study shows that the biological and health impacts of environmental toxicant TCE do not end in maternal adults, but are passed on to offspring generations. Hence, linking observed liver abnormality in the offspring to environmental exposure of their parental line. This study also illustrates that oxidative stress and apoptosis appear to be a molecular component of the hepatocyte cell injury.

Key words: Parental transmission; Hepatocyte cell injury; Oxidative stress; Apoptosis.


 
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How to Cite this Article
Pubmed Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai. Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice. Open Vet J. 2017; 7(3): 244-253. doi:10.4314/ovj.v7i3.8


Web Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai. Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice. https://www.openveterinaryjournal.com/?mno=257071 [Access: April 10, 2024]. doi:10.4314/ovj.v7i3.8


AMA (American Medical Association) Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai. Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice. Open Vet J. 2017; 7(3): 244-253. doi:10.4314/ovj.v7i3.8



Vancouver/ICMJE Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai. Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice. Open Vet J. (2017), [cited April 10, 2024]; 7(3): 244-253. doi:10.4314/ovj.v7i3.8



Harvard Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai (2017) Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice. Open Vet J, 7 (3), 244-253. doi:10.4314/ovj.v7i3.8



Turabian Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai. 2017. Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice. Open Veterinary Journal, 7 (3), 244-253. doi:10.4314/ovj.v7i3.8



Chicago Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai. "Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice." Open Veterinary Journal 7 (2017), 244-253. doi:10.4314/ovj.v7i3.8



MLA (The Modern Language Association) Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai. "Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice." Open Veterinary Journal 7.3 (2017), 244-253. Print. doi:10.4314/ovj.v7i3.8



APA (American Psychological Association) Style

Mohamed Al-Griw, Soad Treesh, Rabia Alghazeer, Sassia Regeai (2017) Environmentally induced Intragenerational Transmission of Liver Abnormalities in Mice. Open Veterinary Journal, 7 (3), 244-253. doi:10.4314/ovj.v7i3.8