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Case Report


Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results

Roberta Troia, Chiara Agnoli, Federico Fracassi, Giuliano Bettini, Alessandra Sfacteria, Luciano Pisoni, Francesco Dondi.


Cited By:5

Abstract
This report documents a case of secondary inappropriate erythrocytosis in a cat with renal cell adenocarcinoma, its stabilization through manual erythrocytapheresis, and the EPO-immunostaining on the affected kidney. An 11-year-old cat was presented with lethargy, weight loss and polyuria/polydipsia. An abdominal mass was detected upon physical examination. Clinicopathological work-up revealed marked erythrocytosis (HCT value 64.8%), renal azotemia and decreased urine specific gravity (USG). An abdominal ultrasound was performed, localizing the mass in the right kidney. Serum erythropoietin (EPO) was above the reference interval (RI), and the cytology of the mass was indicative of renal carcinoma. Manual erythrocytapheresis was performed in order to stabilize the patient before surgery, improving the cat’s clinical and clinicopathological condition. After nephrectomy, EPO and creatinine concentrations returned within the RI, while the USG markedly increased. Histopathology confirmed the diagnosis of renal adenocarcinoma. Immunohistochemistry with anti-EPO antibody revealed diffuse and strong cytoplasmatic positivity in tumor cells.

Key words: Erythropoietin, Feline, Immunohistochemistry, Manual erythrocytapheresis, Renal neoplasia


 
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How to Cite this Article
Pubmed Style

Troia R, Agnoli C, Fracassi F, Bettini G, Sfacteria A, Pisoni L, Dondi F. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. Open Vet J. 2017; 7(4): 294-299. doi:10.4314/ovj.v7i4.1

Web Style

Troia R, Agnoli C, Fracassi F, Bettini G, Sfacteria A, Pisoni L, Dondi F. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. https://www.openveterinaryjournal.com/?mno=260482 [Access: May 08, 2025]. doi:10.4314/ovj.v7i4.1

AMA (American Medical Association) Style

Troia R, Agnoli C, Fracassi F, Bettini G, Sfacteria A, Pisoni L, Dondi F. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. Open Vet J. 2017; 7(4): 294-299. doi:10.4314/ovj.v7i4.1


Vancouver/ICMJE Style

Troia R, Agnoli C, Fracassi F, Bettini G, Sfacteria A, Pisoni L, Dondi F. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. Open Vet J. (2017), [cited May 08, 2025]; 7(4): 294-299. doi:10.4314/ovj.v7i4.1


Harvard Style

Troia, R., Agnoli, . C., Fracassi, . F., Bettini, . G., Sfacteria, . A., Pisoni, . L. & Dondi, . F. (2017) Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. Open Vet J, 7 (4), 294-299. doi:10.4314/ovj.v7i4.1


Turabian Style

Troia, Roberta, Chiara Agnoli, Federico Fracassi, Giuliano Bettini, Alessandra Sfacteria, Luciano Pisoni, and Francesco Dondi. 2017. Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. Open Veterinary Journal, 7 (4), 294-299. doi:10.4314/ovj.v7i4.1


Chicago Style

Troia, Roberta, Chiara Agnoli, Federico Fracassi, Giuliano Bettini, Alessandra Sfacteria, Luciano Pisoni, and Francesco Dondi. "Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results." Open Veterinary Journal 7 (2017), 294-299. doi:10.4314/ovj.v7i4.1


MLA (The Modern Language Association) Style

Troia, Roberta, Chiara Agnoli, Federico Fracassi, Giuliano Bettini, Alessandra Sfacteria, Luciano Pisoni, and Francesco Dondi. "Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results." Open Veterinary Journal 7.4 (2017), 294-299. Print. doi:10.4314/ovj.v7i4.1


APA (American Psychological Association) Style

Troia, R., Agnoli, . C., Fracassi, . F., Bettini, . G., Sfacteria, . A., Pisoni, . L. & Dondi, . F. (2017) Renal adenocarcinoma-associated erythrocytosis in a cat: clinicopathological features and immunohistochemical results. Open Veterinary Journal, 7 (4), 294-299. doi:10.4314/ovj.v7i4.1


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