Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases

Toshie Iseri; Yoshinori Tanabe; Hiro Horikirizono; Hiroshi Sunahara; Harumichi Itoh; Yuki Nemoto; Kazuhito Itamoto; Kenji Tani; Hidekazu Tanaka; Munekazu Nakaichi

doi:10.5455/OVJ.2022.v12.i3.15

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Original Article

Open Vet J. 2022; 12(3): 407-413

doi: 10.5455/OVJ.2022.v12.i3.15

Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases

Toshie Iseri, Yoshinori Tanabe, Hiro Horikirizono, Hiroshi Sunahara, Harumichi Itoh, Yuki Nemoto, Kazuhito Itamoto, Kenji Tani, Hidekazu Tanaka, Munekazu Nakaichi.

Cited By:2

Abstract
Background: For optimal treatment, it is important to maintain optimal multi-leaf collimator (MLC) transmission in intensity-modulated radiation therapy (IMRT). However, adjustment of transmissions has not been reported in veterinary medicine.
Aim: This study aimed to demonstrate that appropriate MLC parameter adjustment for IMRT using 4- and 6-MV energy can reduce the need for quality assurance revalidation in real companion animal clinical cases.
Methods: The MLC parameters (leaf transmission and leaf offset) of the treatment planning system were adjusted by evaluating seven plans (10 × 10 cm, 3ABUT, DMLC, 7segA, FOURL, HDMLC, and HIMRT) and 20 pre-clinical cases (10 cases each in 4 and 6 MV groups). Subsequently, 101 IMRT plans of 88 cases (77 dogs and 11 cats) were evaluated for absolute dose of plan target volume (PTV) and organs at risk (OAR) and were analyzed for the relative dose distribution by gamma analysis (3%/3 mm, >10%) using EBT3 film.
Results: After adjustment of the MLC parameters (leaf transmission and leaf offset, 4 MV: 0.008 and 0, 6 MV: 0.005 and 0), the data from 101 plans (4MV: 64 plans and 6MV: 37 plans) treated with IMRT showed PTV <3%, OAR <5%, and gamma analysis pass rates ≥95% in all cases.
Conclusions: Clinically meaningful dose distributions can be created even with a limited validation device if the treatment parameters are adjusted appropriately, even for tumors in canines and felines, where the irradiation field is small, the target is adjacent to the OAR, and the target is often superficial.

Key words: IMRT, Linac, MLC offset, MLC transmission, Radiation therapy

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How to Cite this Article

Pubmed Style

Iseri T, Tanabe Y, Horikirizono H, Sunahara H, Itoh H, Nemoto Y, Itamoto K, Tani K, Tanaka H, Nakaichi M. Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases. Open Vet J. 2022; 12(3): 407-413. doi:10.5455/OVJ.2022.v12.i3.15

Web Style

Iseri T, Tanabe Y, Horikirizono H, Sunahara H, Itoh H, Nemoto Y, Itamoto K, Tani K, Tanaka H, Nakaichi M. Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases. https://www.openveterinaryjournal.com/?mno=5527 [Access: March 19, 2025]. doi:10.5455/OVJ.2022.v12.i3.15

AMA (American Medical Association) Style

Iseri T, Tanabe Y, Horikirizono H, Sunahara H, Itoh H, Nemoto Y, Itamoto K, Tani K, Tanaka H, Nakaichi M. Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases. Open Vet J. 2022; 12(3): 407-413. doi:10.5455/OVJ.2022.v12.i3.15

Vancouver/ICMJE Style

Iseri T, Tanabe Y, Horikirizono H, Sunahara H, Itoh H, Nemoto Y, Itamoto K, Tani K, Tanaka H, Nakaichi M. Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases. Open Vet J. (2022), [cited March 19, 2025]; 12(3): 407-413. doi:10.5455/OVJ.2022.v12.i3.15

Harvard Style

Iseri, T., Tanabe, . Y., Horikirizono, . H., Sunahara, . H., Itoh, . H., Nemoto, . Y., Itamoto, . K., Tani, . K., Tanaka, . H. & Nakaichi, . M. (2022) Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases. Open Vet J, 12 (3), 407-413. doi:10.5455/OVJ.2022.v12.i3.15

Turabian Style

Iseri, Toshie, Yoshinori Tanabe, Hiro Horikirizono, Hiroshi Sunahara, Harumichi Itoh, Yuki Nemoto, Kazuhito Itamoto, Kenji Tani, Hidekazu Tanaka, and Munekazu Nakaichi. 2022. Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases. Open Veterinary Journal, 12 (3), 407-413. doi:10.5455/OVJ.2022.v12.i3.15

Chicago Style

Iseri, Toshie, Yoshinori Tanabe, Hiro Horikirizono, Hiroshi Sunahara, Harumichi Itoh, Yuki Nemoto, Kazuhito Itamoto, Kenji Tani, Hidekazu Tanaka, and Munekazu Nakaichi. "Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases." Open Veterinary Journal 12 (2022), 407-413. doi:10.5455/OVJ.2022.v12.i3.15

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Iseri, T., Tanabe, . Y., Horikirizono, . H., Sunahara, . H., Itoh, . H., Nemoto, . Y., Itamoto, . K., Tani, . K., Tanaka, . H. & Nakaichi, . M. (2022) Adjustment of multi-leaf collimator parameters in 4-MV and 6-MV IMRT: A study of veterinary clinical cases. Open Veterinary Journal, 12 (3), 407-413. doi:10.5455/OVJ.2022.v12.i3.15

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