E-ISSN 2218-6050 | ISSN 2226-4485
 

Original Article


Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs

Mitsuhiro Isaka.

Abstract
Background: Gerontology is a major research topic in veterinary medicine; however, there are few reports on changes in biomarker levels in aged dogs.
Aim: The purpose of this preliminary study was to evaluate the differences in serum biomarker levels between young (less than 36 months) and old (over 108 months) companion dogs.
Methods: We measured the serum concentrations of brain-derived neurotrophic factor (BDNF), osteoprotegerin (OPG), angiotensin II (ANGII), and endothelin-1 (ET-1) in both groups (young: n=16, 19.8±9.3 months old; old: n=16, 155.8±22.8 months old).
Results: Although the concentrations of BDNF did not differ between the two groups, the OPG, ANGII, and ET-1 levels were significantly higher in the old companion dogs than in the young dogs (p<0.05).
Conclusion: OPG, ANGII, and ET-1 concentrations may increase in dogs during aging.

Key words: Angiotensin II, Brain-derived growth factor, Dogs, Endothelin-1, Osteoprotegerin


 
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How to Cite this Article
Pubmed Style

Isaka M, . Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs. Open Vet J. 2022; 12(6): 980-984. doi:10.5455/OVJ.2022.v12.i6.26


Web Style

Isaka M, . Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs. https://www.openveterinaryjournal.com/?mno=68824 [Access: February 05, 2023]. doi:10.5455/OVJ.2022.v12.i6.26


AMA (American Medical Association) Style

Isaka M, . Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs. Open Vet J. 2022; 12(6): 980-984. doi:10.5455/OVJ.2022.v12.i6.26



Vancouver/ICMJE Style

Isaka M, . Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs. Open Vet J. (2022), [cited February 05, 2023]; 12(6): 980-984. doi:10.5455/OVJ.2022.v12.i6.26



Harvard Style

Isaka, M. & (2022) Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs. Open Vet J, 12 (6), 980-984. doi:10.5455/OVJ.2022.v12.i6.26



Turabian Style

Isaka, Mitsuhiro, and . 2022. Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs. Open Veterinary Journal, 12 (6), 980-984. doi:10.5455/OVJ.2022.v12.i6.26



Chicago Style

Isaka, Mitsuhiro, and . "Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs." Open Veterinary Journal 12 (2022), 980-984. doi:10.5455/OVJ.2022.v12.i6.26



MLA (The Modern Language Association) Style

Isaka, Mitsuhiro, and . "Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs." Open Veterinary Journal 12.6 (2022), 980-984. Print. doi:10.5455/OVJ.2022.v12.i6.26



APA (American Psychological Association) Style

Isaka, M. & (2022) Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs. Open Veterinary Journal, 12 (6), 980-984. doi:10.5455/OVJ.2022.v12.i6.26