E-ISSN 2218-6050 | ISSN 2226-4485
 

Review Article


A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review

Norfitriah Mohamed Sohaimi, Mohd Hair Bejo.


Cited By:10

Abstract
Fowl adenovirus (FAdV) is a double-stranded DNA virus with a non-enveloped structure comprising three major proteins known as hexon, penton, and fiber. Molecular analysis which emphasis on hexon and fiber proteins is currently the major focus of curiosity for FAdV antigenicity and pathogenicity. Recently, disease outbreaks associated with FAdV infection such as inclusion body hepatitis (IBH), hepatitis-hydropericardium syndrome (HHS), and gizzard erosion were commonly reported and continue to increase worldwide. Studies on the virulence gene of the virus were intensively conducted to provide a better understanding on the role of these major capsid proteins in the development of a safe and effective vaccine against the disease in the poultry industry. This paper highlighted on variation of the fiber and hexon genes, their importance in genotypes and serotypes differentiation and infectivity between FAdV strains. It appears that the L1 loop of hexon and the knob of fiber genes are the infectivity markers for FAdV infection. The fiber-2 protein plays a major role in FAdV pathogenicity than the hexon protein, whilst the fiber-1 protein is important for viral replication and assembly regardless of virulence capability instead of infectivity. The hexon protein plays a major role in virus infectivity and tissue tropism. These findings could further enhance on the knowledge of FAdV strains classification and evolution, diagnosis, and strategies to prevent and control FAdV infection and outbreaks in chicken farms.

Key words: Fowl adenovirus (FAdV); infectivity; hexon; fiber; antigenicity; pathogenicity


 
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How to Cite this Article
Pubmed Style

Sohaimi NM, Bejo MH. A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review. Open Vet J. 2021; 11(4): 569-580. doi:10.5455/OVJ.2021.v11.i4.6


Web Style

Sohaimi NM, Bejo MH. A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review. https://www.openveterinaryjournal.com/?mno=98642 [Access: February 12, 2024]. doi:10.5455/OVJ.2021.v11.i4.6


AMA (American Medical Association) Style

Sohaimi NM, Bejo MH. A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review. Open Vet J. 2021; 11(4): 569-580. doi:10.5455/OVJ.2021.v11.i4.6



Vancouver/ICMJE Style

Sohaimi NM, Bejo MH. A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review. Open Vet J. (2021), [cited February 12, 2024]; 11(4): 569-580. doi:10.5455/OVJ.2021.v11.i4.6



Harvard Style

Sohaimi, N. M. & Bejo, . M. H. (2021) A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review. Open Vet J, 11 (4), 569-580. doi:10.5455/OVJ.2021.v11.i4.6



Turabian Style

Sohaimi, Norfitriah Mohamed, and Mohd Hair Bejo. 2021. A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review. Open Veterinary Journal, 11 (4), 569-580. doi:10.5455/OVJ.2021.v11.i4.6



Chicago Style

Sohaimi, Norfitriah Mohamed, and Mohd Hair Bejo. "A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review." Open Veterinary Journal 11 (2021), 569-580. doi:10.5455/OVJ.2021.v11.i4.6



MLA (The Modern Language Association) Style

Sohaimi, Norfitriah Mohamed, and Mohd Hair Bejo. "A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review." Open Veterinary Journal 11.4 (2021), 569-580. Print. doi:10.5455/OVJ.2021.v11.i4.6



APA (American Psychological Association) Style

Sohaimi, N. M. & Bejo, . M. H. (2021) A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review. Open Veterinary Journal, 11 (4), 569-580. doi:10.5455/OVJ.2021.v11.i4.6