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Research Article


Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers

Dina R.S. Gad El-Karim, Gamal M. El-Amrawi, Alyaa R. Salama.


Abstract
Background:
Affection with Corynebacterium pseudotuberculosis (C. pseudotuberculosis) and development of cellulitis and/or abscess formation with cutaneous lymphangitis in cattle is rare to some extent, so literature about the biochemical changes that would accompany this infection is rare.
Aim:
In this context, the present study was designed to screen the effect of the infection with C. pseudotuberculosis cutaneous lymphangitis on the release of some immune molecules, organ functions, and redox state in Baladi cows.
Methods:
Fourteen Baladi cows from a small dairy farm in El-Behira, Egypt, were selected to complete this study. After bacteriological culture confirmation, seven of them were found suffering from cutaneous lesions due to infection with C. pseudotuberculosis (Diseased group), while the others were healthy (Healthy group). Serum samples were obtained to evaluate the presumptive changes in some clinicopathological parameters.
Results:
Serum analysis revealed a significant decrease in the levels of interferon-gamma (IFN-γ) and interleukin-17 (IL-17) as well as a significant decrement in the concentration of beta-defensin (β-defensin) and lipocalin-2 (LCN-2). While serum level of interleukin-10 (IL-10) recorded a significant increase in these animals when compared to healthy control animals. Concurrently, the affected animals recorded a significant elevation in serum levels of hepato-cardiac enzymes, urea, and creatinine in addition to disturbance in the serum redox state.
Conclusion:
In conclusion, infection with C. pseudotuberculosis cattle may disturb the defensive immune state, body organ function, and redox state of the animals.

Key words: Corynebacterium pseudotuberculosis, Lymphangitis, Cows, Cytokines, Redox State


 
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How to Cite this Article
Pubmed Style

El-Karim DRG, El-Amrawi GM, Salama AR. Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 25-31. doi:10.5455/OVJ.2024.v14.i1.4

Web Style

El-Karim DRG, El-Amrawi GM, Salama AR. Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers. https://www.openveterinaryjournal.com/?mno=174659 [Access: May 02, 2024]. doi:10.5455/OVJ.2024.v14.i1.4

AMA (American Medical Association) Style

El-Karim DRG, El-Amrawi GM, Salama AR. Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers. Open Vet J. 2024; 14((1) (Zagazig Veterinary Conference)): 25-31. doi:10.5455/OVJ.2024.v14.i1.4


Vancouver/ICMJE Style

El-Karim DRG, El-Amrawi GM, Salama AR. Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers. Open Vet J. (2024), [cited May 02, 2024]; 14((1) (Zagazig Veterinary Conference)): 25-31. doi:10.5455/OVJ.2024.v14.i1.4


Harvard Style

El-Karim, D. R. G., El-Amrawi, . G. M. & Salama, . A. R. (2024) Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers. Open Vet J, 14 ((1) (Zagazig Veterinary Conference)), 25-31. doi:10.5455/OVJ.2024.v14.i1.4


Turabian Style

El-Karim, Dina R.S. Gad, Gamal M. El-Amrawi, and Alyaa R. Salama. 2024. Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 25-31. doi:10.5455/OVJ.2024.v14.i1.4


Chicago Style

El-Karim, Dina R.S. Gad, Gamal M. El-Amrawi, and Alyaa R. Salama. "Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers." Open Veterinary Journal 14 (2024), 25-31. doi:10.5455/OVJ.2024.v14.i1.4


MLA (The Modern Language Association) Style

El-Karim, Dina R.S. Gad, Gamal M. El-Amrawi, and Alyaa R. Salama. "Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers." Open Veterinary Journal 14.(1) (Zagazig Veterinary Conference) (2024), 25-31. Print. doi:10.5455/OVJ.2024.v14.i1.4


APA (American Psychological Association) Style

El-Karim, D. R. G., El-Amrawi, . G. M. & Salama, . A. R. (2024) Clinicopathological studies on ulcerative lymphangitis in cattle: Alterations in serum inflammatory cytokines, anti-microbial, organs functions and oxidative stress-related biomarkers. Open Veterinary Journal, 14 ((1) (Zagazig Veterinary Conference)), 25-31. doi:10.5455/OVJ.2024.v14.i1.4


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