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Review Article


Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine

Sri Mulyati, Fedik Abdul Rantam, Aswin Rafif Khairullah, Imam Mustofa, Adeyinka Oye Akintunde, Riza Zainuddin Ahmad, Ulvi Fitri Handayani, Andi Thafida Khalisa, Lili Anggraini, Bima Putra Pratama, Latifah Latifah, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, Syahputra Wibowo.


Abstract
The application of biotechnology is an attempt to improve animal reproduction efficiency, specifically to produce cattle of high quality and quantity. One method that is seen to be successful and efficient in the field of reproduction is embryo transfer. The capacity of donor females to produce embryos limits the amount of embryos that can be produced in vivo. An alternate source of embryos in this instance is in vitro embryo production. It has been demonstrated that two mitogenic chemicals, estrogen and insulin-like growth factor-I (IGF-I), can be employed to promote and speed up cell proliferation. The polypeptide growth factor IGF-I, also known as somatomedin, is released by the liver and other tissues in reaction to growth hormone stimulation. The molecular weight of the 70 amino acids that make up IGF-I is 7649 Dalton, or 7.65 kDa. Specifically produced by developing follicles in the ovary, corpora lutea, and placenta, estrogen is a steroid hormone with a molecular weight of 300–400 Dalton (272.3 Dalton). IGF-I and estrogen promote mitogenic activity in proliferating cells in paracrine, autocrine, and endocrine ways. IGF-I and estrogen can be produced by the liver and ovaries. Both the ovary and the liver are the primary producers of the sex steroid estrogen and IGF-I, respectively, and both may be produced using monolayer cell culture by supplementing them with either bovine serum albumine (BSA) or foetal calf serum (FCS) as precursor substances. According to the descriptions, IGF-I and the steroid sex hormones progesterone and estrogen in liver and cumulus cell monolayer culture may be used as a culture medium for embryo development.

Key words: Bovine IVF; Embryo development; IGF-1; Sex steroids; Cumulus cells.


 
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How to Cite this Article
Pubmed Style

Mulyati S, Rantam FA, Khairullah AR, Mustofa I, Akintunde AO, Ahmad RZ, Handayani UF, Khalisa AT, Anggraini L, Pratama BP, Latifah L, Wardhani BWK, Kurniasih DAA, Wibowo S. Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine. Open Vet. J.. 2025; 15(9): 3961-3979. doi:10.5455/OVJ.2025.v15.i9.4

Web Style

Mulyati S, Rantam FA, Khairullah AR, Mustofa I, Akintunde AO, Ahmad RZ, Handayani UF, Khalisa AT, Anggraini L, Pratama BP, Latifah L, Wardhani BWK, Kurniasih DAA, Wibowo S. Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine. https://www.openveterinaryjournal.com/?mno=250013 [Access: October 06, 2025]. doi:10.5455/OVJ.2025.v15.i9.4

AMA (American Medical Association) Style

Mulyati S, Rantam FA, Khairullah AR, Mustofa I, Akintunde AO, Ahmad RZ, Handayani UF, Khalisa AT, Anggraini L, Pratama BP, Latifah L, Wardhani BWK, Kurniasih DAA, Wibowo S. Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine. Open Vet. J.. 2025; 15(9): 3961-3979. doi:10.5455/OVJ.2025.v15.i9.4


Vancouver/ICMJE Style

Mulyati S, Rantam FA, Khairullah AR, Mustofa I, Akintunde AO, Ahmad RZ, Handayani UF, Khalisa AT, Anggraini L, Pratama BP, Latifah L, Wardhani BWK, Kurniasih DAA, Wibowo S. Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine. Open Vet. J.. (2025), [cited October 06, 2025]; 15(9): 3961-3979. doi:10.5455/OVJ.2025.v15.i9.4


Harvard Style

Mulyati, S., Rantam, . F. A., Khairullah, . A. R., Mustofa, . I., Akintunde, . A. O., Ahmad, . R. Z., Handayani, . U. F., Khalisa, . A. T., Anggraini, . L., Pratama, . B. P., Latifah, . L., Wardhani, . B. W. K., Kurniasih, . D. A. A. & Wibowo, . S. (2025) Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine. Open Vet. J., 15 (9), 3961-3979. doi:10.5455/OVJ.2025.v15.i9.4


Turabian Style

Mulyati, Sri, Fedik Abdul Rantam, Aswin Rafif Khairullah, Imam Mustofa, Adeyinka Oye Akintunde, Riza Zainuddin Ahmad, Ulvi Fitri Handayani, Andi Thafida Khalisa, Lili Anggraini, Bima Putra Pratama, Latifah Latifah, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, and Syahputra Wibowo. 2025. Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine. Open Veterinary Journal, 15 (9), 3961-3979. doi:10.5455/OVJ.2025.v15.i9.4


Chicago Style

Mulyati, Sri, Fedik Abdul Rantam, Aswin Rafif Khairullah, Imam Mustofa, Adeyinka Oye Akintunde, Riza Zainuddin Ahmad, Ulvi Fitri Handayani, Andi Thafida Khalisa, Lili Anggraini, Bima Putra Pratama, Latifah Latifah, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, and Syahputra Wibowo. "Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine." Open Veterinary Journal 15 (2025), 3961-3979. doi:10.5455/OVJ.2025.v15.i9.4


MLA (The Modern Language Association) Style

Mulyati, Sri, Fedik Abdul Rantam, Aswin Rafif Khairullah, Imam Mustofa, Adeyinka Oye Akintunde, Riza Zainuddin Ahmad, Ulvi Fitri Handayani, Andi Thafida Khalisa, Lili Anggraini, Bima Putra Pratama, Latifah Latifah, Bantari Wisynu Kusuma Wardhani, Dea Anita Ariani Kurniasih, and Syahputra Wibowo. "Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine." Open Veterinary Journal 15.9 (2025), 3961-3979. Print. doi:10.5455/OVJ.2025.v15.i9.4


APA (American Psychological Association) Style

Mulyati, S., Rantam, . F. A., Khairullah, . A. R., Mustofa, . I., Akintunde, . A. O., Ahmad, . R. Z., Handayani, . U. F., Khalisa, . A. T., Anggraini, . L., Pratama, . B. P., Latifah, . L., Wardhani, . B. W. K., Kurniasih, . D. A. A. & Wibowo, . S. (2025) Potential of growth factors and steroid hormones from cell cultures to improve in vitro fertilization in bovine. Open Veterinary Journal, 15 (9), 3961-3979. doi:10.5455/OVJ.2025.v15.i9.4


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