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Research Article


NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings

Intan Permatasari Hermawan, Palestin Palestin, Ady Kurnianto, Hana Cipka Pramuda Wardhani, Dian Ayu Kartika Sari.


Abstract
Background:
Heart diseases are common in dogs, geriatric, overweight, to obese individuals, with metabolic problems, lack of nutrition, and breed problems. NT-proBNP and cardiac troponin-I (cTnI) are selected for the diagnosis of heart damage in early detection. Both of these biomarkers have another function. This study compared NT-proBNP with cTnI for the early detection of cardiac diseases in dogs.

Aim:
This study compared NT-proBNP with cTnI levels for the early detection of cardiac diseases in dogs.

Methods:
A total of five dogs of various breeds, ages, sexes, and body weights were included. All animals underwent a comprehensive diagnostic workup, including a thorough history and physical examination, cardiorespiratory auscultation, and laboratory diagnostics. These diagnostics include blood pressure measurement, thoracic radiography, and echocardiography, which are performed on every patient, and biomarker levels used a commercial kit rapid test (®Flash test).

Results:
Four dogs had a cardiac troponin I level of >0.1 ng/ml (abnormal), and 1 dog has a normal cTnI level, but four dogs had a normal NT-proBNP level ≤ 2 ng/ml, but 1 dog has an abnormal level. Every dog has laboratory results based on blood pressure, electrocardiography, X-ray, and echocardiography per case. Based on cardiographic results relevant with cTnI that more sensitive if asymptomatic patients rather than NT-proBNP

Conclusion:
cTnI is more sensitive than NT-proBNP, supported by other laboratory examinations to establish a more accurate diagnosis. However, a larger number of case samples is needed to draw a more accurate diagnosis.

Key words: NT-proBNP, cTn-I; Cardiography; Dogs.


 
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How to Cite this Article
Pubmed Style

Hermawan IP, Palestin P, Kurnianto A, Wardhani HCP, Sari DAK. NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings. Open Vet. J.. 2025; 15(12): 6245-6252. doi:10.5455/OVJ.2025.v15.i12.9

Web Style

Hermawan IP, Palestin P, Kurnianto A, Wardhani HCP, Sari DAK. NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings. https://www.openveterinaryjournal.com/?mno=278721 [Access: December 31, 2025]. doi:10.5455/OVJ.2025.v15.i12.9

AMA (American Medical Association) Style

Hermawan IP, Palestin P, Kurnianto A, Wardhani HCP, Sari DAK. NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings. Open Vet. J.. 2025; 15(12): 6245-6252. doi:10.5455/OVJ.2025.v15.i12.9


Vancouver/ICMJE Style

Hermawan IP, Palestin P, Kurnianto A, Wardhani HCP, Sari DAK. NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings. Open Vet. J.. (2025), [cited December 31, 2025]; 15(12): 6245-6252. doi:10.5455/OVJ.2025.v15.i12.9


Harvard Style

Hermawan, I. P., Palestin, . P., Kurnianto, . A., Wardhani, . H. C. P. & Sari, . D. A. K. (2025) NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings. Open Vet. J., 15 (12), 6245-6252. doi:10.5455/OVJ.2025.v15.i12.9


Turabian Style

Hermawan, Intan Permatasari, Palestin Palestin, Ady Kurnianto, Hana Cipka Pramuda Wardhani, and Dian Ayu Kartika Sari. 2025. NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings. Open Veterinary Journal, 15 (12), 6245-6252. doi:10.5455/OVJ.2025.v15.i12.9


Chicago Style

Hermawan, Intan Permatasari, Palestin Palestin, Ady Kurnianto, Hana Cipka Pramuda Wardhani, and Dian Ayu Kartika Sari. "NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings." Open Veterinary Journal 15 (2025), 6245-6252. doi:10.5455/OVJ.2025.v15.i12.9


MLA (The Modern Language Association) Style

Hermawan, Intan Permatasari, Palestin Palestin, Ady Kurnianto, Hana Cipka Pramuda Wardhani, and Dian Ayu Kartika Sari. "NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings." Open Veterinary Journal 15.12 (2025), 6245-6252. Print. doi:10.5455/OVJ.2025.v15.i12.9


APA (American Psychological Association) Style

Hermawan, I. P., Palestin, . P., Kurnianto, . A., Wardhani, . H. C. P. & Sari, . D. A. K. (2025) NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings. Open Veterinary Journal, 15 (12), 6245-6252. doi:10.5455/OVJ.2025.v15.i12.9


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